HEADER LIGASE 19-MAR-05 1Z5S TITLE CRYSTAL STRUCTURE OF A COMPLEX BETWEEN UBC9, SUMO-1, TITLE 2 RANGAP1 AND NUP358/RANBP2 COMPND MOL_ID: 1; COMPND 2 MOLECULE: UBIQUITIN-CONJUGATING ENZYME E2 I; COMPND 3 CHAIN: A; COMPND 4 SYNONYM: UBIQUITIN-PROTEIN LIGASE I, UBIQUITIN CARRIER COMPND 5 PROTEIN I, SUMO-1-PROTEIN LIGASE, SUMO- 1 CONJUGATING COMPND 6 ENZYME, UBIQUITIN CARRIER PROTEIN 9, P18; COMPND 7 EC: 6.3.2.19; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 2; COMPND 10 MOLECULE: UBIQUITIN-LIKE PROTEIN SMT3C; COMPND 11 CHAIN: B; COMPND 12 SYNONYM: UBIQUITIN-HOMOLOGY DOMAIN PROTEIN PIC1, UBIQUITIN- COMPND 13 LIKE PROTEIN UBL1, UBIQUITIN-RELATED PROTEIN SUMO-1, GAP COMPND 14 MODIFYING PROTEIN 1, GMP1, SENTRIN, OK/SW-CL.43; COMPND 15 ENGINEERED: YES; COMPND 16 MOL_ID: 3; COMPND 17 MOLECULE: RAN GTPASE-ACTIVATING PROTEIN 1; COMPND 18 CHAIN: C; COMPND 19 FRAGMENT: C-TERMINAL DOMAIN; COMPND 20 ENGINEERED: YES; COMPND 21 MOL_ID: 4; COMPND 22 MOLECULE: RAN-BINDING PROTEIN 2; COMPND 23 CHAIN: D; COMPND 24 FRAGMENT: IR1-M DOMAIN; COMPND 25 SYNONYM: RANBP2, NUCLEAR PORE COMPLEX PROTEIN NUP358, COMPND 26 NUCLEOPORIN NUP358, 358 KDA NUCLEOPORIN, P270; COMPND 27 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 GENE: UBE2I, UBC9, UBCE9; SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); SOURCE 7 EXPRESSION_SYSTEM_TAXID: 469008; SOURCE 8 EXPRESSION_SYSTEM_STRAIN: BL21DE3; SOURCE 9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; SOURCE 10 EXPRESSION_SYSTEM_PLASMID: PET28B; SOURCE 11 MOL_ID: 2; SOURCE 12 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 13 ORGANISM_COMMON: HUMAN; SOURCE 14 ORGANISM_TAXID: 9606; SOURCE 15 GENE: UBL1, SMT3C, SMT3H3; SOURCE 16 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); SOURCE 17 EXPRESSION_SYSTEM_TAXID: 469008; SOURCE 18 EXPRESSION_SYSTEM_STRAIN: BL21DE3; SOURCE 19 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; SOURCE 20 EXPRESSION_SYSTEM_PLASMID: PET28B; SOURCE 21 MOL_ID: 3; SOURCE 22 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 23 ORGANISM_COMMON: HUMAN; SOURCE 24 ORGANISM_TAXID: 9606; SOURCE 25 GENE: RANGAP1; SOURCE 26 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); SOURCE 27 EXPRESSION_SYSTEM_TAXID: 469008; SOURCE 28 EXPRESSION_SYSTEM_STRAIN: BL21DE3; SOURCE 29 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; SOURCE 30 EXPRESSION_SYSTEM_PLASMID: PSMT3; SOURCE 31 MOL_ID: 4; SOURCE 32 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 33 ORGANISM_COMMON: HUMAN; SOURCE 34 ORGANISM_TAXID: 9606; SOURCE 35 GENE: RANBP2, NUP358; SOURCE 36 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3); SOURCE 37 EXPRESSION_SYSTEM_TAXID: 469008; SOURCE 38 EXPRESSION_SYSTEM_STRAIN: BL21DE3; SOURCE 39 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; SOURCE 40 EXPRESSION_SYSTEM_PLASMID: PSMT3 KEYWDS E3, LIGASE, SUMO, UBC9, NUCLEAR PORE COMPLEX EXPDTA X-RAY DIFFRACTION AUTHOR D.REVERTER,C.D.LIMA REVDAT 2 24-FEB-09 1Z5S 1 VERSN REVDAT 1 07-JUN-05 1Z5S 0 JRNL AUTH D.REVERTER,C.D.LIMA JRNL TITL INSIGHTS INTO E3 LIGASE ACTIVITY REVEALED BY A JRNL TITL 2 SUMO-RANGAP1-UBC9-NUP358 COMPLEX. JRNL REF NATURE V. 435 687 2005 JRNL REFN ISSN 0028-0836 JRNL PMID 15931224 JRNL DOI 10.1038/NATURE03588 REMARK 1 REMARK 2 REMARK 2 RESOLUTION. 3.01 ANGSTROMS. REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM : CNS 1.1 REMARK 3 AUTHORS : BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE- REMARK 3 : KUNSTLEVE,JIANG,KUSZEWSKI,NILGES, PANNU, REMARK 3 : READ,RICE,SIMONSON,WARREN REMARK 3 REMARK 3 REFINEMENT TARGET : ENGH & HUBER REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 3.01 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 29.69 REMARK 3 DATA CUTOFF (SIGMA(F)) : 0.000 REMARK 3 DATA CUTOFF HIGH (ABS(F)) : 2281669.870 REMARK 3 DATA CUTOFF LOW (ABS(F)) : 0.0000 REMARK 3 COMPLETENESS (WORKING+TEST) (%) : 96.5 REMARK 3 NUMBER OF REFLECTIONS : 16461 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD : THROUGHOUT REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM REMARK 3 R VALUE (WORKING SET) : 0.247 REMARK 3 FREE R VALUE : 0.290 REMARK 3 FREE R VALUE TEST SET SIZE (%) : 5.100 REMARK 3 FREE R VALUE TEST SET COUNT : 832 REMARK 3 ESTIMATED ERROR OF FREE R VALUE : 0.010 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 6 REMARK 3 BIN RESOLUTION RANGE HIGH (A) : 3.01 REMARK 3 BIN RESOLUTION RANGE LOW (A) : 3.19 REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) : 86.20 REMARK 3 REFLECTIONS IN BIN (WORKING SET) : 2299 REMARK 3 BIN R VALUE (WORKING SET) : 0.4250 REMARK 3 BIN FREE R VALUE : 0.4320 REMARK 3 BIN FREE R VALUE TEST SET SIZE (%) : 5.00 REMARK 3 BIN FREE R VALUE TEST SET COUNT : 122 REMARK 3 ESTIMATED ERROR OF BIN FREE R VALUE : 0.039 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 PROTEIN ATOMS : 3564 REMARK 3 NUCLEIC ACID ATOMS : 0 REMARK 3 HETEROGEN ATOMS : 0 REMARK 3 SOLVENT ATOMS : 28 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2) : 74.00 REMARK 3 MEAN B VALUE (OVERALL, A**2) : 90.00 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2) : -15.45000 REMARK 3 B22 (A**2) : -15.45000 REMARK 3 B33 (A**2) : 30.91000 REMARK 3 B12 (A**2) : 17.61000 REMARK 3 B13 (A**2) : 0.00000 REMARK 3 B23 (A**2) : 0.00000 REMARK 3 REMARK 3 ESTIMATED COORDINATE ERROR. REMARK 3 ESD FROM LUZZATI PLOT (A) : 0.47 REMARK 3 ESD FROM SIGMAA (A) : 0.99 REMARK 3 LOW RESOLUTION CUTOFF (A) : 8.00 REMARK 3 REMARK 3 CROSS-VALIDATED ESTIMATED COORDINATE ERROR. REMARK 3 ESD FROM C-V LUZZATI PLOT (A) : 0.57 REMARK 3 ESD FROM C-V SIGMAA (A) : 1.16 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES. REMARK 3 BOND LENGTHS (A) : 0.006 REMARK 3 BOND ANGLES (DEGREES) : 1.20 REMARK 3 DIHEDRAL ANGLES (DEGREES) : 21.40 REMARK 3 IMPROPER ANGLES (DEGREES) : 0.84 REMARK 3 REMARK 3 ISOTROPIC THERMAL MODEL : RESTRAINED REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. RMS SIGMA REMARK 3 MAIN-CHAIN BOND (A**2) : 2.270 ; 2.000 REMARK 3 MAIN-CHAIN ANGLE (A**2) : 3.980 ; 3.500 REMARK 3 SIDE-CHAIN BOND (A**2) : 2.800 ; 2.500 REMARK 3 SIDE-CHAIN ANGLE (A**2) : 4.720 ; 4.000 REMARK 3 REMARK 3 BULK SOLVENT MODELING. REMARK 3 METHOD USED : FLAT MODEL REMARK 3 KSOL : 0.27 REMARK 3 BSOL : 13.94 REMARK 3 REMARK 3 NCS MODEL : NULL REMARK 3 REMARK 3 NCS RESTRAINTS. RMS SIGMA/WEIGHT REMARK 3 GROUP 1 POSITIONAL (A) : NULL ; NULL REMARK 3 GROUP 1 B-FACTOR (A**2) : NULL ; NULL REMARK 3 REMARK 3 PARAMETER FILE 1 : PROTEIN_REP.PARAM REMARK 3 PARAMETER FILE 2 : DNA-RNA_REP.PARAM REMARK 3 PARAMETER FILE 3 : WATER_REP.PARAM REMARK 3 PARAMETER FILE 4 : ION.PARAM REMARK 3 PARAMETER FILE 5 : NULL REMARK 3 TOPOLOGY FILE 1 : PROTEIN.TOP REMARK 3 TOPOLOGY FILE 2 : DNA-RNA.TOP REMARK 3 TOPOLOGY FILE 3 : WATER.TOP REMARK 3 TOPOLOGY FILE 4 : ION.TOP REMARK 3 TOPOLOGY FILE 5 : NULL REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: BULK SOLVENT MODEL USED REMARK 4 REMARK 4 1Z5S COMPLIES WITH FORMAT V. 3.15, 01-DEC-08 REMARK 100 REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 30-MAR-05. REMARK 100 THE RCSB ID CODE IS RCSB032333. REMARK 200 REMARK 200 EXPERIMENTAL DETAILS REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION REMARK 200 DATE OF DATA COLLECTION : 24-AUG-04 REMARK 200 TEMPERATURE (KELVIN) : 100 REMARK 200 PH : 5.0 REMARK 200 NUMBER OF CRYSTALS USED : 1 REMARK 200 REMARK 200 SYNCHROTRON (Y/N) : Y REMARK 200 RADIATION SOURCE : APS REMARK 200 BEAMLINE : 31-ID REMARK 200 X-RAY GENERATOR MODEL : NULL REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M REMARK 200 WAVELENGTH OR RANGE (A) : 0.9793 REMARK 200 MONOCHROMATOR : DIAMOND REMARK 200 OPTICS : NULL REMARK 200 REMARK 200 DETECTOR TYPE : CCD REMARK 200 DETECTOR MANUFACTURER : MARRESEARCH REMARK 200 INTENSITY-INTEGRATION SOFTWARE : DENZO REMARK 200 DATA SCALING SOFTWARE : SCALEPACK REMARK 200 REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 16464 REMARK 200 RESOLUTION RANGE HIGH (A) : 3.000 REMARK 200 RESOLUTION RANGE LOW (A) : 50.000 REMARK 200 REJECTION CRITERIA (SIGMA(I)) : 0.000 REMARK 200 REMARK 200 OVERALL. REMARK 200 COMPLETENESS FOR RANGE (%) : 97.0 REMARK 200 DATA REDUNDANCY : NULL REMARK 200 R MERGE (I) : 0.07500 REMARK 200 R SYM (I) : NULL REMARK 200 FOR THE DATA SET : 15.1000 REMARK 200 REMARK 200 IN THE HIGHEST RESOLUTION SHELL. REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.00 REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 3.11 REMARK 200 COMPLETENESS FOR SHELL (%) : 91.8 REMARK 200 DATA REDUNDANCY IN SHELL : NULL REMARK 200 R MERGE FOR SHELL (I) : 0.46400 REMARK 200 R SYM FOR SHELL (I) : NULL REMARK 200 FOR SHELL : 2.100 REMARK 200 REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT REMARK 200 SOFTWARE USED: MOLREP REMARK 200 STARTING MODEL: RANGAP1-UBC9 COMPLEX REMARK 200 REMARK 200 REMARK: NULL REMARK 280 REMARK 280 CRYSTAL REMARK 280 SOLVENT CONTENT, VS (%): 67.73 REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 3.81 REMARK 280 REMARK 280 CRYSTALLIZATION CONDITIONS: 18% PEG4000 (W/V), 0.1 M SODIUM REMARK 280 CITRATE, 0.2 M AMMONIUM ACETATE, PH 5.0, VAPOR DIFFUSION, REMARK 280 HANGING DROP, TEMPERATURE 291K REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 32 2 1 REMARK 290 REMARK 290 SYMOP SYMMETRY REMARK 290 NNNMMM OPERATOR REMARK 290 1555 X,Y,Z REMARK 290 2555 -Y,X-Y,Z+2/3 REMARK 290 3555 -X+Y,-X,Z+1/3 REMARK 290 4555 Y,X,-Z REMARK 290 5555 X-Y,-Y,-Z+1/3 REMARK 290 6555 -X,-X+Y,-Z+2/3 REMARK 290 REMARK 290 WHERE NNN -> OPERATOR NUMBER REMARK 290 MMM -> TRANSLATION VECTOR REMARK 290 REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY REMARK 290 RELATED MOLECULES. REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000 REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000 REMARK 290 SMTRY1 2 -0.500000 -0.866025 0.000000 0.00000 REMARK 290 SMTRY2 2 0.866025 -0.500000 0.000000 0.00000 REMARK 290 SMTRY3 2 0.000000 0.000000 1.000000 39.74200 REMARK 290 SMTRY1 3 -0.500000 0.866025 0.000000 0.00000 REMARK 290 SMTRY2 3 -0.866025 -0.500000 0.000000 0.00000 REMARK 290 SMTRY3 3 0.000000 0.000000 1.000000 19.87100 REMARK 290 SMTRY1 4 -0.500000 0.866025 0.000000 0.00000 REMARK 290 SMTRY2 4 0.866025 0.500000 0.000000 0.00000 REMARK 290 SMTRY3 4 0.000000 0.000000 -1.000000 0.00000 REMARK 290 SMTRY1 5 1.000000 0.000000 0.000000 0.00000 REMARK 290 SMTRY2 5 0.000000 -1.000000 0.000000 0.00000 REMARK 290 SMTRY3 5 0.000000 0.000000 -1.000000 19.87100 REMARK 290 SMTRY1 6 -0.500000 -0.866025 0.000000 0.00000 REMARK 290 SMTRY2 6 -0.866025 0.500000 0.000000 0.00000 REMARK 290 SMTRY3 6 0.000000 0.000000 -1.000000 39.74200 REMARK 290 REMARK 290 REMARK: NULL REMARK 300 REMARK 300 BIOMOLECULE: 1 REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON REMARK 300 BURIED SURFACE AREA. REMARK 350 REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN. REMARK 350 REMARK 350 BIOMOLECULE: 1 REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TETRAMERIC REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000 REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000 REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000 REMARK 465 REMARK 465 MISSING RESIDUES REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.) REMARK 465 REMARK 465 M RES C SSSEQI REMARK 465 MET A 1 REMARK 465 SER A 158 REMARK 465 MET B 16 REMARK 465 GLY B 17 REMARK 465 GLU B 18 REMARK 465 GLY B 19 REMARK 465 SER C 416 REMARK 465 LEU C 417 REMARK 465 ASN C 418 REMARK 465 THR C 419 REMARK 465 GLY C 420 REMARK 465 GLU C 421 REMARK 465 PRO C 422 REMARK 465 ALA C 423 REMARK 465 PRO C 424 REMARK 465 VAL C 425 REMARK 465 LEU C 426 REMARK 465 SER C 427 REMARK 465 SER C 428 REMARK 465 PRO C 429 REMARK 465 PRO C 430 REMARK 465 PRO C 431 REMARK 465 GLU D 2694 REMARK 465 LYS D 2695 REMARK 465 CYS D 2696 REMARK 465 ARG D 2697 REMARK 465 PRO D 2698 REMARK 465 LEU D 2699 REMARK 465 GLU D 2700 REMARK 465 GLU D 2701 REMARK 465 ASN D 2702 REMARK 465 THR D 2703 REMARK 465 ALA D 2704 REMARK 465 ASP D 2705 REMARK 465 ASN D 2706 REMARK 465 GLU D 2707 REMARK 465 LYS D 2708 REMARK 465 GLU D 2709 REMARK 465 CYS D 2710 REMARK 465 ILE D 2711 REMARK 470 REMARK 470 MISSING ATOM REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS(M=MODEL NUMBER; REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER; REMARK 470 I=INSERTION CODE): REMARK 470 M RES CSSEQI ATOMS REMARK 470 SER A 2 CB OG REMARK 470 LYS A 18 CG CD CE NZ REMARK 470 LYS A 49 CG CD CE NZ REMARK 470 GLU B 83 CG CD OE1 OE2 REMARK 470 LYS C 452 CG CD CE NZ REMARK 470 LYS C 553 CG CD CE NZ REMARK 470 LYS C 586 CG CD CE NZ REMARK 470 LYS D2650 CD CE NZ REMARK 470 ARG D2663 CD NE CZ NH1 NH2 REMARK 470 ASP D2665 OD1 OD2 REMARK 470 TYR D2666 CD1 CD2 CE1 CE2 CZ OH REMARK 470 GLU D2669 CD OE1 OE2 REMARK 470 GLU D2670 CD OE1 OE2 REMARK 470 LYS D2683 CG CD CE NZ REMARK 500 REMARK 500 GEOMETRY AND STEREOCHEMISTRY REMARK 500 SUBTOPIC: TORSION ANGLES REMARK 500 REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS: REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER; REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE). REMARK 500 REMARK 500 STANDARD TABLE: REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2) REMARK 500 REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI- REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400 REMARK 500 REMARK 500 M RES CSSEQI PSI PHI REMARK 500 PRO A 28 -174.63 -63.89 REMARK 500 THR A 29 -164.26 -111.71 REMARK 500 ASP A 33 -7.93 -48.76 REMARK 500 THR A 35 -171.71 -56.25 REMARK 500 TYR A 68 143.62 -29.38 REMARK 500 PRO A 84 -34.88 -35.87 REMARK 500 TYR A 87 162.92 -49.41 REMARK 500 LYS A 101 -90.01 -136.46 REMARK 500 GLU A 122 67.87 -119.45 REMARK 500 ASN A 124 63.57 -107.83 REMARK 500 ILE A 125 -17.78 -49.80 REMARK 500 ASP A 127 79.63 178.40 REMARK 500 ASP B 30 27.84 -166.34 REMARK 500 MET B 40 23.01 -68.20 REMARK 500 GLN B 55 -5.54 -144.84 REMARK 500 MET B 59 -34.00 -39.55 REMARK 500 SER B 61 -41.91 -20.73 REMARK 500 ARG B 63 133.53 -171.33 REMARK 500 THR B 76 145.81 -178.64 REMARK 500 PRO B 77 -12.96 -46.04 REMARK 500 GLU B 83 -152.79 -73.50 REMARK 500 GLU B 85 -0.73 67.23 REMARK 500 ASP B 86 174.38 -49.61 REMARK 500 PRO C 441 174.39 -46.34 REMARK 500 SER C 442 136.08 178.79 REMARK 500 ARG C 448 32.65 -68.54 REMARK 500 LYS C 452 30.87 -91.86 REMARK 500 SER C 454 2.98 -55.66 REMARK 500 VAL C 455 -20.09 -148.58 REMARK 500 ALA C 458 44.85 -69.09 REMARK 500 GLN C 459 -47.72 -166.21 REMARK 500 ASP C 462 82.70 -68.40 REMARK 500 THR C 463 2.96 -63.74 REMARK 500 SER C 464 -81.21 -61.18 REMARK 500 SER C 478 6.59 -56.14 REMARK 500 ASP C 482 -2.93 -52.41 REMARK 500 GLU C 483 172.26 -47.27 REMARK 500 LYS C 500 -71.26 -66.23 REMARK 500 SER C 504 83.80 167.31 REMARK 500 SER C 505 -25.27 -29.95 REMARK 500 SER C 506 44.34 -72.22 REMARK 500 LEU C 513 -35.53 -39.16 REMARK 500 MET C 520 32.67 -90.33 REMARK 500 ASP C 527 -158.91 -141.67 REMARK 500 ALA C 533 -81.57 -53.56 REMARK 500 TYR C 550 4.95 -58.49 REMARK 500 LYS C 553 8.55 -58.04 REMARK 500 SER C 568 -72.75 -30.12 REMARK 500 LEU C 570 12.09 -65.44 REMARK 500 CYS C 573 46.80 -153.06 REMARK 500 PHE C 575 -72.87 -57.97 REMARK 500 PRO D2655 -35.18 -32.18 REMARK 500 THR D2656 52.22 -94.57 REMARK 500 ASP D2665 -145.49 -60.17 REMARK 500 TYR D2666 99.24 -46.22 REMARK 500 SER D2668 -124.74 -163.17 REMARK 500 GLU D2669 49.75 -171.41 REMARK 500 GLU D2670 125.83 -172.04 REMARK 500 GLU D2671 137.23 176.29 REMARK 500 ASP D2674 -31.22 -161.38 REMARK 500 GLU D2675 139.14 -32.83 REMARK 500 ASN D2685 -75.16 18.02 REMARK 500 LYS D2687 173.59 -47.89 REMARK 500 ASP D2691 108.30 -44.98 REMARK 500 REMARK 500 REMARK: NULL REMARK 900 REMARK 900 RELATED ENTRIES REMARK 900 RELATED ID: 1KPS RELATED DB: PDB REMARK 900 PUTATIVE SUBSTRATE COMPLEX BETWEEN UBC9 AND RANGAP1 REMARK 999 REMARK 999 SEQUENCE REMARK 999 COVALENT ISOPEPTIDE BOND BETWEEN RANGAP1 LYS524 AND REMARK 999 SUMO C-TERMINUS GLY97. DBREF 1Z5S A 1 158 UNP P63279 UBE2I_HUMAN 1 158 DBREF 1Z5S B 18 97 UNP P63165 SUMO1_HUMAN 18 97 DBREF 1Z5S C 418 587 UNP P46060 RGP1_HUMAN 418 587 DBREF 1Z5S D 2631 2711 UNP P49792 RBP2_HUMAN 2631 2711 SEQADV 1Z5S MET B 16 UNP P63165 CLONING ARTIFACT SEQADV 1Z5S GLY B 17 UNP P63165 CLONING ARTIFACT SEQADV 1Z5S SER C 416 UNP P46060 CLONING ARTIFACT SEQADV 1Z5S LEU C 417 UNP P46060 CLONING ARTIFACT SEQADV 1Z5S SER D 2629 UNP P49792 CLONING ARTIFACT SEQADV 1Z5S LEU D 2630 UNP P49792 CLONING ARTIFACT SEQRES 1 A 158 MET SER GLY ILE ALA LEU SER ARG LEU ALA GLN GLU ARG SEQRES 2 A 158 LYS ALA TRP ARG LYS ASP HIS PRO PHE GLY PHE VAL ALA SEQRES 3 A 158 VAL PRO THR LYS ASN PRO ASP GLY THR MET ASN LEU MET SEQRES 4 A 158 ASN TRP GLU CYS ALA ILE PRO GLY LYS LYS GLY THR PRO SEQRES 5 A 158 TRP GLU GLY GLY LEU PHE LYS LEU ARG MET LEU PHE LYS SEQRES 6 A 158 ASP ASP TYR PRO SER SER PRO PRO LYS CYS LYS PHE GLU SEQRES 7 A 158 PRO PRO LEU PHE HIS PRO ASN VAL TYR PRO SER GLY THR SEQRES 8 A 158 VAL CYS LEU SER ILE LEU GLU GLU ASP LYS ASP TRP ARG SEQRES 9 A 158 PRO ALA ILE THR ILE LYS GLN ILE LEU LEU GLY ILE GLN SEQRES 10 A 158 GLU LEU LEU ASN GLU PRO ASN ILE GLN ASP PRO ALA GLN SEQRES 11 A 158 ALA GLU ALA TYR THR ILE TYR CYS GLN ASN ARG VAL GLU SEQRES 12 A 158 TYR GLU LYS ARG VAL ARG ALA GLN ALA LYS LYS PHE ALA SEQRES 13 A 158 PRO SER SEQRES 1 B 82 MET GLY GLU GLY GLU TYR ILE LYS LEU LYS VAL ILE GLY SEQRES 2 B 82 GLN ASP SER SER GLU ILE HIS PHE LYS VAL LYS MET THR SEQRES 3 B 82 THR HIS LEU LYS LYS LEU LYS GLU SER TYR CYS GLN ARG SEQRES 4 B 82 GLN GLY VAL PRO MET ASN SER LEU ARG PHE LEU PHE GLU SEQRES 5 B 82 GLY GLN ARG ILE ALA ASP ASN HIS THR PRO LYS GLU LEU SEQRES 6 B 82 GLY MET GLU GLU GLU ASP VAL ILE GLU VAL TYR GLN GLU SEQRES 7 B 82 GLN THR GLY GLY SEQRES 1 C 172 SER LEU ASN THR GLY GLU PRO ALA PRO VAL LEU SER SER SEQRES 2 C 172 PRO PRO PRO ALA ASP VAL SER THR PHE LEU ALA PHE PRO SEQRES 3 C 172 SER PRO GLU LYS LEU LEU ARG LEU GLY PRO LYS SER SER SEQRES 4 C 172 VAL LEU ILE ALA GLN GLN THR ASP THR SER ASP PRO GLU SEQRES 5 C 172 LYS VAL VAL SER ALA PHE LEU LYS VAL SER SER VAL PHE SEQRES 6 C 172 LYS ASP GLU ALA THR VAL ARG MET ALA VAL GLN ASP ALA SEQRES 7 C 172 VAL ASP ALA LEU MET GLN LYS ALA PHE ASN SER SER SER SEQRES 8 C 172 PHE ASN SER ASN THR PHE LEU THR ARG LEU LEU VAL HIS SEQRES 9 C 172 MET GLY LEU LEU LYS SER GLU ASP LYS VAL LYS ALA ILE SEQRES 10 C 172 ALA ASN LEU TYR GLY PRO LEU MET ALA LEU ASN HIS MET SEQRES 11 C 172 VAL GLN GLN ASP TYR PHE PRO LYS ALA LEU ALA PRO LEU SEQRES 12 C 172 LEU LEU ALA PHE VAL THR LYS PRO ASN SER ALA LEU GLU SEQRES 13 C 172 SER CYS SER PHE ALA ARG HIS SER LEU LEU GLN THR LEU SEQRES 14 C 172 TYR LYS VAL SEQRES 1 D 83 SER LEU ASP VAL LEU ILE VAL TYR GLU LEU THR PRO THR SEQRES 2 D 83 ALA GLU GLN LYS ALA LEU ALA THR LYS LEU LYS LEU PRO SEQRES 3 D 83 PRO THR PHE PHE CYS TYR LYS ASN ARG PRO ASP TYR VAL SEQRES 4 D 83 SER GLU GLU GLU GLU ASP ASP GLU ASP PHE GLU THR ALA SEQRES 5 D 83 VAL LYS LYS LEU ASN GLY LYS LEU TYR LEU ASP GLY SER SEQRES 6 D 83 GLU LYS CYS ARG PRO LEU GLU GLU ASN THR ALA ASP ASN SEQRES 7 D 83 GLU LYS GLU CYS ILE FORMUL 5 HOH *28(H2 O) HELIX 35 35 ILE A 4 ASP A 19 1 16 HELIX 36 36 LEU A 94 GLU A 98 1 5 HELIX 37 37 THR A 108 GLU A 122 1 15 HELIX 38 38 GLN A 130 LYS A 154 1 25 HELIX 39 39 HIS B 43 ARG B 54 1 12 HELIX 40 40 THR B 76 GLY B 81 1 6 HELIX 41 41 ALA C 432 PHE C 440 1 9 HELIX 42 42 LEU C 446 SER C 454 1 9 HELIX 43 43 LEU C 456 THR C 461 1 6 HELIX 44 44 ASP C 465 SER C 478 1 14 HELIX 45 45 ALA C 484 PHE C 502 1 19 HELIX 46 46 ASN C 508 MET C 520 1 13 HELIX 47 47 LEU C 535 VAL C 546 1 12 HELIX 48 48 LEU C 555 LYS C 565 1 11 HELIX 49 49 SER C 568 VAL C 587 1 20 HELIX 50 50 THR D 2641 LEU D 2651 1 11 HELIX 51 51 ASP D 2676 LEU D 2684 1 9 SHEET 21 21 1 VAL A 25 LYS A 30 0 SHEET 22 22 1 MET A 36 PRO A 46 0 SHEET 23 23 1 LEU A 57 LEU A 63 0 SHEET 24 24 1 LYS A 74 PHE A 77 0 SHEET 25 25 1 ILE B 22 ILE B 27 0 SHEET 26 26 1 GLU B 33 VAL B 38 0 SHEET 27 27 1 PHE B 64 PHE B 66 0 SHEET 28 28 1 GLN B 69 ARG B 70 0 SHEET 29 29 1 VAL B 87 VAL B 90 0 SHEET 30 30 1 VAL D2632 GLU D2637 0 LINK C GLY B 97 NZ LYS C 524 1555 1555 1.33 CISPEP 1 TYR A 68 PRO A 69 0 -0.05 CISPEP 2 GLU A 78 PRO A 79 0 -0.09 CRYST1 157.123 157.123 59.613 90.00 90.00 120.00 P 32 2 1 6 ORIGX1 1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000 0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1 0.006364 0.003675 0.000000 0.00000 SCALE2 0.000000 0.007349 0.000000 0.00000 SCALE3 0.000000 0.000000 0.016775 0.00000 TER 1954 GLY B 97 ATOM 1955 N ALA C 432 47.998 101.799 75.322 1.00113.52 N ATOM 1956 CA ALA C 432 47.916 100.970 76.520 1.00115.15 C ATOM 1957 C ALA C 432 46.749 99.987 76.433 1.00116.12 C ATOM 1958 O ALA C 432 46.771 98.928 77.065 1.00113.78 O ATOM 1959 CB ALA C 432 47.769 101.854 77.757 1.00113.97 C ATOM 1960 N ASP C 433 45.732 100.348 75.651 1.00119.02 N ATOM 1961 CA ASP C 433 44.552 99.502 75.463 1.00120.72 C ATOM 1962 C ASP C 433 44.826 98.459 74.395 1.00120.47 C ATOM 1963 O ASP C 433 44.656 97.260 74.627 1.00120.26 O ATOM 1964 CB ASP C 433 43.334 100.333 75.041 1.00122.25 C ATOM 1965 CG ASP C 433 42.716 101.098 76.195 1.00123.24 C ATOM 1966 OD1 ASP C 433 42.415 100.467 77.232 1.00122.31 O ATOM 1967 OD2 ASP C 433 42.523 102.324 76.061 1.00124.68 O ATOM 1968 N VAL C 434 45.235 98.925 73.218 1.00119.59 N ATOM 1969 CA VAL C 434 45.549 98.022 72.121 1.00118.63 C ATOM 1970 C VAL C 434 46.499 96.951 72.651 1.00117.49 C ATOM 1971 O VAL C 434 46.317 95.758 72.392 1.00118.21 O ATOM 1972 CB VAL C 434 46.217 98.772 70.937 1.00117.28 C ATOM 1973 CG1 VAL C 434 45.169 99.504 70.123 1.00115.60 C ATOM 1974 CG2 VAL C 434 47.244 99.760 71.461 1.00117.96 C ATOM 1975 N SER C 435 47.499 97.387 73.411 1.00114.26 N ATOM 1976 CA SER C 435 48.473 96.477 73.990 1.00110.17 C ATOM 1977 C SER C 435 47.765 95.280 74.615 1.00108.32 C ATOM 1978 O SER C 435 47.849 94.165 74.097 1.00108.99 O ATOM 1979 CB SER C 435 49.300 97.201 75.052 1.00109.26 C ATOM 1980 OG SER C 435 50.212 96.311 75.671 1.00109.94 O ATOM 1981 N THR C 436 47.058 95.518 75.716 1.00105.53 N ATOM 1982 CA THR C 436 46.334 94.458 76.413 1.00102.75 C ATOM 1983 C THR C 436 45.325 93.720 75.534 1.00102.10 C ATOM 1984 O THR C 436 45.023 92.551 75.783 1.00102.13 O ATOM 1985 CB THR C 436 45.603 95.010 77.646 1.00101.40 C ATOM 1986 OG1 THR C 436 45.027 96.281 77.324 1.00102.63 O ATOM 1987 CG2 THR C 436 46.561 95.159 78.819 1.00 99.93 C ATOM 1988 N PHE C 437 44.799 94.389 74.512 1.00 99.85 N ATOM 1989 CA PHE C 437 43.845 93.741 73.619 1.00 96.96 C ATOM 1990 C PHE C 437 44.538 92.660 72.812 1.00 96.63 C ATOM 1991 O PHE C 437 43.965 91.601 72.555 1.00 95.07 O ATOM 1992 CB PHE C 437 43.223 94.744 72.653 1.00 95.28 C ATOM 1993 CG PHE C 437 42.528 94.100 71.488 1.00 94.31 C ATOM 1994 CD1 PHE C 437 41.527 93.159 71.693 1.00 93.77 C ATOM 1995 CD2 PHE C 437 42.878 94.430 70.184 1.00 94.69 C ATOM 1996 CE1 PHE C 437 40.884 92.556 70.615 1.00 93.53 C ATOM 1997 CE2 PHE C 437 42.240 93.833 69.101 1.00 93.85 C ATOM 1998 CZ PHE C 437 41.242 92.895 69.318 1.00 93.23 C ATOM 1999 N LEU C 438 45.773 92.943 72.408 1.00 97.49 N ATOM 2000 CA LEU C 438 46.564 92.006 71.624 1.00 99.53 C ATOM 2001 C LEU C 438 47.024 90.825 72.451 1.00 99.85 C ATOM 2002 O LEU C 438 47.215 89.730 71.922 1.00 99.61 O ATOM 2003 CB LEU C 438 47.779 92.707 71.024 1.00102.32 C ATOM 2004 CG LEU C 438 47.447 93.713 69.921 1.00106.32 C ATOM 2005 CD1 LEU C 438 48.734 94.327 69.386 1.00108.07 C ATOM 2006 CD2 LEU C 438 46.676 93.014 68.803 1.00105.47 C ATOM 2007 N ALA C 439 47.212 91.047 73.747 1.00101.45 N ATOM 2008 CA ALA C 439 47.635 89.976 74.642 1.00103.90 C ATOM 2009 C ALA C 439 46.534 88.915 74.688 1.00106.03 C ATOM 2010 O ALA C 439 46.772 87.738 74.396 1.00108.00 O ATOM 2011 CB ALA C 439 47.902 90.529 76.039 1.00101.12 C ATOM 2012 N PHE C 440 45.327 89.341 75.049 1.00104.17 N ATOM 2013 CA PHE C 440 44.189 88.435 75.120 1.00100.25 C ATOM 2014 C PHE C 440 43.033 89.031 74.341 1.00 97.87 C ATOM 2015 O PHE C 440 42.246 89.808 74.872 1.00 96.99 O ATOM 2016 CB PHE C 440 43.784 88.211 76.571 1.00 99.83 C ATOM 2017 CG PHE C 440 44.900 87.712 77.432 1.00101.22 C ATOM 2018 CD1 PHE C 440 45.960 88.546 77.769 1.00100.73 C ATOM 2019 CD2 PHE C 440 44.912 86.396 77.882 1.00103.65 C ATOM 2020 CE1 PHE C 440 47.018 88.079 78.540 1.00102.16 C ATOM 2021 CE2 PHE C 440 45.968 85.915 78.657 1.00104.49 C ATOM 2022 CZ PHE C 440 47.023 86.760 78.985 1.00104.33 C ATOM 2023 N PRO C 441 42.926 88.677 73.056 1.00 97.43 N ATOM 2024 CA PRO C 441 41.867 89.171 72.174 1.00 97.69 C ATOM 2025 C PRO C 441 40.486 89.107 72.808 1.00 98.22 C ATOM 2026 O PRO C 441 40.318 88.582 73.911 1.00 98.22 O ATOM 2027 CB PRO C 441 41.988 88.264 70.959 1.00 97.12 C ATOM 2028 CG PRO C 441 43.466 88.033 70.891 1.00 99.12 C ATOM 2029 CD PRO C 441 43.822 87.755 72.335 1.00 97.51 C ATOM 2030 N SER C 442 39.505 89.649 72.096 1.00 97.59 N ATOM 2031 CA SER C 442 38.122 89.682 72.550 1.00 94.83 C ATOM 2032 C SER C 442 37.267 90.396 71.518 1.00 96.19 C ATOM 2033 O SER C 442 37.650 91.437 70.987 1.00 96.45 O ATOM 2034 CB SER C 442 38.007 90.418 73.883 1.00 91.51 C ATOM 2035 OG SER C 442 36.648 90.571 74.250 1.00 87.15 O ATOM 2036 N PRO C 443 36.090 89.839 71.215 1.00 98.07 N ATOM 2037 CA PRO C 443 35.182 90.440 70.234 1.00 99.08 C ATOM 2038 C PRO C 443 34.666 91.771 70.759 1.00 99.85 C ATOM 2039 O PRO C 443 34.187 92.612 70.000 1.00 99.76 O ATOM 2040 CB PRO C 443 34.059 89.409 70.120 1.00 98.65 C ATOM 2041 CG PRO C 443 34.719 88.119 70.540 1.00 99.59 C ATOM 2042 CD PRO C 443 35.570 88.549 71.694 1.00 98.25 C ATOM 2043 N GLU C 444 34.782 91.945 72.072 1.00101.27 N ATOM 2044 CA GLU C 444 34.309 93.142 72.751 1.00101.47 C ATOM 2045 C GLU C 444 35.412 94.148 73.038 1.00 99.53 C ATOM 2046 O GLU C 444 35.308 95.307 72.642 1.00 98.19 O ATOM 2047 CB GLU C 444 33.624 92.739 74.055 1.00104.85 C ATOM 2048 CG GLU C 444 32.615 91.619 73.862 1.00111.33 C ATOM 2049 CD GLU C 444 31.986 91.162 75.157 1.00115.55 C ATOM 2050 OE1 GLU C 444 32.746 90.816 76.088 1.00117.85 O ATOM 2051 OE2 GLU C 444 30.736 91.143 75.238 1.00116.48 O ATOM 2052 N LYS C 445 36.460 93.703 73.731 1.00 98.14 N ATOM 2053 CA LYS C 445 37.581 94.575 74.069 1.00 97.35 C ATOM 2054 C LYS C 445 37.992 95.432 72.879 1.00 99.39 C ATOM 2055 O LYS C 445 38.458 96.562 73.050 1.00 99.40 O ATOM 2056 CB LYS C 445 38.771 93.745 74.556 1.00 94.38 C ATOM 2057 CG LYS C 445 38.529 93.088 75.901 1.00 94.83 C ATOM 2058 CD LYS C 445 39.717 92.259 76.371 1.00 94.20 C ATOM 2059 CE LYS C 445 39.396 91.579 77.700 1.00 93.33 C ATOM 2060 NZ LYS C 445 40.480 90.691 78.195 1.00 90.43 N ATOM 2061 N LEU C 446 37.812 94.890 71.676 1.00100.45 N ATOM 2062 CA LEU C 446 38.141 95.601 70.441 1.00 99.75 C ATOM 2063 C LEU C 446 37.265 96.848 70.350 1.00100.17 C ATOM 2064 O LEU C 446 37.752 97.962 70.146 1.00 99.67 O ATOM 2065 CB LEU C 446 37.880 94.704 69.223 1.00 97.31 C ATOM 2066 CG LEU C 446 38.134 95.335 67.848 1.00 95.50 C ATOM 2067 CD1 LEU C 446 39.628 95.566 67.685 1.00 95.41 C ATOM 2068 CD2 LEU C 446 37.604 94.438 66.733 1.00 91.47 C ATOM 2069 N LEU C 447 35.963 96.637 70.505 1.00100.57 N ATOM 2070 CA LEU C 447 34.980 97.711 70.450 1.00101.04 C ATOM 2071 C LEU C 447 35.245 98.764 71.525 1.00101.85 C ATOM 2072 O LEU C 447 35.088 99.963 71.285 1.00101.41 O ATOM 2073 CB LEU C 447 33.582 97.125 70.646 1.00 99.65 C ATOM 2074 CG LEU C 447 33.147 96.061 69.637 1.00 97.23 C ATOM 2075 CD1 LEU C 447 32.050 95.205 70.244 1.00 95.88 C ATOM 2076 CD2 LEU C 447 32.689 96.733 68.346 1.00 94.62 C ATOM 2077 N ARG C 448 35.650 98.305 72.707 1.00101.80 N ATOM 2078 CA ARG C 448 35.924 99.192 73.830 1.00102.56 C ATOM 2079 C ARG C 448 37.163 100.064 73.606 1.00103.43 C ATOM 2080 O ARG C 448 37.877 100.400 74.552 1.00103.24 O ATOM 2081 CB ARG C 448 36.088 98.370 75.111 1.00103.12 C ATOM 2082 CG ARG C 448 35.907 99.172 76.393 1.00108.34 C ATOM 2083 CD ARG C 448 34.539 99.852 76.416 1.00114.05 C ATOM 2084 NE ARG C 448 34.331 100.680 77.604 1.00117.10 N ATOM 2085 CZ ARG C 448 33.361 101.584 77.723 1.00117.57 C ATOM 2086 NH1 ARG C 448 32.509 101.782 76.722 1.00117.05 N ATOM 2087 NH2 ARG C 448 33.242 102.295 78.839 1.00117.14 N ATOM 2088 N LEU C 449 37.410 100.432 72.352 1.00103.17 N ATOM 2089 CA LEU C 449 38.554 101.268 72.006 1.00101.29 C ATOM 2090 C LEU C 449 38.064 102.486 71.236 1.00 98.77 C ATOM 2091 O LEU C 449 38.857 103.306 70.771 1.00 98.70 O ATOM 2092 CB LEU C 449 39.550 100.487 71.142 1.00103.77 C ATOM 2093 CG LEU C 449 40.111 99.163 71.673 1.00104.91 C ATOM 2094 CD1 LEU C 449 41.021 98.566 70.618 1.00104.91 C ATOM 2095 CD2 LEU C 449 40.870 99.374 72.978 1.00104.04 C ATOM 2096 N GLY C 450 36.748 102.597 71.102 1.00 96.08 N ATOM 2097 CA GLY C 450 36.177 103.723 70.392 1.00 94.24 C ATOM 2098 C GLY C 450 36.421 103.575 68.911 1.00 93.61 C ATOM 2099 O GLY C 450 36.982 102.570 68.487 1.00 90.81 O ATOM 2100 N PRO C 451 36.005 104.555 68.094 1.00 97.10 N ATOM 2101 CA PRO C 451 36.208 104.479 66.642 1.00 98.97 C ATOM 2102 C PRO C 451 37.677 104.665 66.282 1.00101.10 C ATOM 2103 O PRO C 451 38.076 104.509 65.127 1.00 99.36 O ATOM 2104 CB PRO C 451 35.324 105.608 66.111 1.00 96.58 C ATOM 2105 CG PRO C 451 35.409 106.635 67.204 1.00 95.90 C ATOM 2106 CD PRO C 451 35.300 105.796 68.469 1.00 96.81 C ATOM 2107 N LYS C 452 38.474 104.989 67.297 1.00104.16 N ATOM 2108 CA LYS C 452 39.901 105.217 67.129 1.00106.41 C ATOM 2109 C LYS C 452 40.725 103.950 67.348 1.00108.78 C ATOM 2110 O LYS C 452 41.868 104.015 67.802 1.00109.65 O ATOM 2111 CB LYS C 452 40.367 106.307 68.098 1.00106.01 C ATOM 2112 N SER C 453 40.139 102.799 67.028 1.00109.35 N ATOM 2113 CA SER C 453 40.819 101.513 67.174 1.00106.41 C ATOM 2114 C SER C 453 41.289 101.088 65.791 1.00103.38 C ATOM 2115 O SER C 453 42.370 100.516 65.623 1.00101.74 O ATOM 2116 CB SER C 453 39.855 100.468 67.733 1.00106.41 C ATOM 2117 OG SER C 453 38.706 100.367 66.911 1.00108.57 O ATOM 2118 N SER C 454 40.457 101.388 64.800 1.00100.71 N ATOM 2119 CA SER C 454 40.760 101.065 63.419 1.00100.51 C ATOM 2120 C SER C 454 42.103 101.662 63.004 1.00100.86 C ATOM 2121 O SER C 454 42.508 101.552 61.845 1.00102.67 O ATOM 2122 CB SER C 454 39.654 101.596 62.508 1.00 99.70 C ATOM 2123 OG SER C 454 39.981 101.382 61.149 1.00 99.44 O ATOM 2124 N VAL C 455 42.785 102.303 63.951 1.00 98.53 N ATOM 2125 CA VAL C 455 44.082 102.913 63.691 1.00 94.91 C ATOM 2126 C VAL C 455 44.948 102.871 64.943 1.00 92.63 C ATOM 2127 O VAL C 455 46.166 102.985 64.869 1.00 91.55 O ATOM 2128 CB VAL C 455 43.942 104.385 63.218 1.00 93.20 C ATOM 2129 CG1 VAL C 455 45.308 104.948 62.870 1.00 92.96 C ATOM 2130 CG2 VAL C 455 43.030 104.466 61.999 1.00 90.78 C ATOM 2131 N LEU C 456 44.323 102.709 66.101 1.00 93.39 N ATOM 2132 CA LEU C 456 45.092 102.639 67.332 1.00 97.41 C ATOM 2133 C LEU C 456 45.897 101.347 67.256 1.00 98.78 C ATOM 2134 O LEU C 456 47.016 101.258 67.768 1.00 97.34 O ATOM 2135 CB LEU C 456 44.164 102.608 68.551 1.00 99.87 C ATOM 2136 CG LEU C 456 44.644 103.278 69.848 1.00100.82 C ATOM 2137 CD1 LEU C 456 43.588 103.086 70.921 1.00102.11 C ATOM 2138 CD2 LEU C 456 45.976 102.698 70.307 1.00102.17 C ATOM 2139 N ILE C 457 45.315 100.344 66.607 1.00101.30 N ATOM 2140 CA ILE C 457 45.979 99.058 66.450 1.00104.19 C ATOM 2141 C ILE C 457 46.832 99.113 65.193 1.00105.59 C ATOM 2142 O ILE C 457 48.005 98.740 65.210 1.00105.00 O ATOM 2143 CB ILE C 457 44.976 97.905 66.283 1.00105.17 C ATOM 2144 CG1 ILE C 457 43.837 98.035 67.294 1.00107.02 C ATOM 2145 CG2 ILE C 457 45.692 96.578 66.496 1.00104.59 C ATOM 2146 CD1 ILE C 457 42.785 96.937 67.169 1.00107.36 C ATOM 2147 N ALA C 458 46.230 99.580 64.102 1.00107.60 N ATOM 2148 CA ALA C 458 46.933 99.695 62.827 1.00109.87 C ATOM 2149 C ALA C 458 47.996 100.792 62.895 1.00112.09 C ATOM 2150 O ALA C 458 48.124 101.617 61.987 1.00112.41 O ATOM 2151 CB ALA C 458 45.940 99.990 61.707 1.00106.84 C ATOM 2152 N GLN C 459 48.750 100.795 63.989 1.00113.39 N ATOM 2153 CA GLN C 459 49.814 101.765 64.208 1.00114.71 C ATOM 2154 C GLN C 459 50.675 101.277 65.361 1.00114.43 C ATOM 2155 O GLN C 459 51.901 101.263 65.274 1.00115.26 O ATOM 2156 CB GLN C 459 49.243 103.141 64.561 1.00116.17 C ATOM 2157 CG GLN C 459 50.325 104.189 64.790 1.00120.19 C ATOM 2158 CD GLN C 459 49.838 105.397 65.575 1.00123.02 C ATOM 2159 OE1 GLN C 459 49.423 105.279 66.730 1.00122.96 O ATOM 2160 NE2 GLN C 459 49.896 106.567 64.952 1.00125.66 N ATOM 2161 N GLN C 460 50.021 100.879 66.445 1.00114.03 N ATOM 2162 CA GLN C 460 50.723 100.389 67.619 1.00114.55 C ATOM 2163 C GLN C 460 51.449 99.103 67.241 1.00115.80 C ATOM 2164 O GLN C 460 52.333 98.639 67.962 1.00115.36 O ATOM 2165 CB GLN C 460 49.723 100.139 68.751 1.00114.81 C ATOM 2166 CG GLN C 460 50.346 99.997 70.135 1.00117.05 C ATOM 2167 CD GLN C 460 50.825 98.588 70.441 1.00117.82 C ATOM 2168 OE1 GLN C 460 51.395 98.331 71.504 1.00116.69 O ATOM 2169 NE2 GLN C 460 50.586 97.666 69.518 1.00119.95 N ATOM 2170 N THR C 461 51.077 98.543 66.092 1.00117.36 N ATOM 2171 CA THR C 461 51.678 97.306 65.598 1.00117.81 C ATOM 2172 C THR C 461 52.886 97.578 64.704 1.00116.94 C ATOM 2173 O THR C 461 52.851 98.454 63.837 1.00117.71 O ATOM 2174 CB THR C 461 50.668 96.482 64.781 1.00118.55 C ATOM 2175 OG1 THR C 461 49.458 96.325 65.528 1.00121.10 O ATOM 2176 CG2 THR C 461 51.237 95.112 64.477 1.00119.94 C ATOM 2177 N ASP C 462 53.950 96.809 64.916 1.00114.23 N ATOM 2178 CA ASP C 462 55.178 96.954 64.140 1.00111.32 C ATOM 2179 C ASP C 462 54.960 96.521 62.688 1.00107.58 C ATOM 2180 O ASP C 462 55.278 95.395 62.311 1.00106.57 O ATOM 2181 CB ASP C 462 56.284 96.109 64.779 1.00113.10 C ATOM 2182 CG ASP C 462 57.625 96.300 64.108 1.00115.03 C ATOM 2183 OD1 ASP C 462 57.676 96.220 62.866 1.00114.71 O ATOM 2184 OD2 ASP C 462 58.628 96.520 64.821 1.00116.99 O ATOM 2185 N THR C 463 54.423 97.426 61.878 1.00104.64 N ATOM 2186 CA THR C 463 54.140 97.145 60.472 1.00104.33 C ATOM 2187 C THR C 463 55.381 96.852 59.628 1.00105.63 C ATOM 2188 O THR C 463 55.286 96.641 58.416 1.00103.94 O ATOM 2189 CB THR C 463 53.373 98.322 59.835 1.00104.30 C ATOM 2190 OG1 THR C 463 53.286 98.137 58.415 1.00103.52 O ATOM 2191 CG2 THR C 463 54.077 99.629 60.145 1.00105.04 C ATOM 2192 N SER C 464 56.542 96.827 60.274 1.00108.43 N ATOM 2193 CA SER C 464 57.800 96.573 59.575 1.00108.67 C ATOM 2194 C SER C 464 57.846 95.204 58.899 1.00108.49 C ATOM 2195 O SER C 464 57.606 95.094 57.693 1.00108.45 O ATOM 2196 CB SER C 464 58.988 96.690 60.542 1.00108.15 C ATOM 2197 OG SER C 464 58.976 97.917 61.254 1.00106.75 O ATOM 2198 N ASP C 465 58.148 94.171 59.691 1.00107.57 N ATOM 2199 CA ASP C 465 58.274 92.797 59.197 1.00105.89 C ATOM 2200 C ASP C 465 56.981 91.979 59.164 1.00100.67 C ATOM 2201 O ASP C 465 56.144 92.063 60.065 1.00 98.76 O ATOM 2202 CB ASP C 465 59.333 92.040 60.012 1.00109.85 C ATOM 2203 CG ASP C 465 58.814 91.572 61.361 1.00112.29 C ATOM 2204 OD1 ASP C 465 58.253 92.404 62.107 1.00112.47 O ATOM 2205 OD2 ASP C 465 58.975 90.370 61.671 1.00112.80 O ATOM 2206 N PRO C 466 56.822 91.155 58.115 1.00 95.72 N ATOM 2207 CA PRO C 466 55.655 90.303 57.912 1.00 91.24 C ATOM 2208 C PRO C 466 55.215 89.521 59.134 1.00 87.82 C ATOM 2209 O PRO C 466 54.046 89.551 59.496 1.00 89.01 O ATOM 2210 CB PRO C 466 56.096 89.394 56.771 1.00 92.29 C ATOM 2211 CG PRO C 466 56.964 90.296 55.958 1.00 92.07 C ATOM 2212 CD PRO C 466 57.797 90.962 57.025 1.00 94.55 C ATOM 2213 N GLU C 467 56.148 88.831 59.776 1.00 85.82 N ATOM 2214 CA GLU C 467 55.804 88.018 60.936 1.00 88.05 C ATOM 2215 C GLU C 467 54.891 88.729 61.933 1.00 88.94 C ATOM 2216 O GLU C 467 53.899 88.154 62.387 1.00 89.94 O ATOM 2217 CB GLU C 467 57.072 87.532 61.643 1.00 90.49 C ATOM 2218 CG GLU C 467 56.825 86.527 62.781 1.00 93.44 C ATOM 2219 CD GLU C 467 56.264 85.178 62.312 1.00 94.61 C ATOM 2220 OE1 GLU C 467 56.080 84.284 63.168 1.00 94.92 O ATOM 2221 OE2 GLU C 467 56.006 85.003 61.100 1.00 92.60 O ATOM 2222 N LYS C 468 55.213 89.971 62.277 1.00 88.98 N ATOM 2223 CA LYS C 468 54.389 90.715 63.225 1.00 87.66 C ATOM 2224 C LYS C 468 53.048 91.101 62.609 1.00 83.64 C ATOM 2225 O LYS C 468 52.018 91.072 63.281 1.00 81.03 O ATOM 2226 CB LYS C 468 55.136 91.956 63.727 1.00 90.70 C ATOM 2227 CG LYS C 468 56.256 91.632 64.724 1.00 92.25 C ATOM 2228 CD LYS C 468 57.083 92.865 65.077 1.00 93.51 C ATOM 2229 CE LYS C 468 58.260 92.518 65.982 1.00 93.18 C ATOM 2230 NZ LYS C 468 59.225 93.652 66.102 1.00 92.63 N ATOM 2231 N VAL C 469 53.057 91.461 61.331 1.00 81.23 N ATOM 2232 CA VAL C 469 51.820 91.809 60.649 1.00 80.44 C ATOM 2233 C VAL C 469 50.892 90.605 60.783 1.00 84.94 C ATOM 2234 O VAL C 469 49.739 90.739 61.192 1.00 89.63 O ATOM 2235 CB VAL C 469 52.046 92.070 59.148 1.00 76.55 C ATOM 2236 CG1 VAL C 469 50.742 92.485 58.494 1.00 71.39 C ATOM 2237 CG2 VAL C 469 53.099 93.134 58.957 1.00 76.56 C ATOM 2238 N VAL C 470 51.411 89.429 60.437 1.00 84.80 N ATOM 2239 CA VAL C 470 50.655 88.184 60.519 1.00 83.31 C ATOM 2240 C VAL C 470 50.058 87.999 61.907 1.00 82.77 C ATOM 2241 O VAL C 470 48.878 87.676 62.039 1.00 83.32 O ATOM 2242 CB VAL C 470 51.549 86.969 60.207 1.00 84.15 C ATOM 2243 CG1 VAL C 470 50.785 85.676 60.453 1.00 84.39 C ATOM 2244 CG2 VAL C 470 52.018 87.032 58.769 1.00 86.53 C ATOM 2245 N SER C 471 50.873 88.201 62.939 1.00 81.19 N ATOM 2246 CA SER C 471 50.409 88.056 64.314 1.00 81.05 C ATOM 2247 C SER C 471 49.215 88.967 64.598 1.00 80.80 C ATOM 2248 O SER C 471 48.191 88.524 65.127 1.00 81.31 O ATOM 2249 CB SER C 471 51.535 88.379 65.291 1.00 82.39 C ATOM 2250 OG SER C 471 51.080 88.254 66.629 1.00 85.59 O ATOM 2251 N ALA C 472 49.354 90.244 64.256 1.00 78.67 N ATOM 2252 CA ALA C 472 48.278 91.203 64.464 1.00 75.68 C ATOM 2253 C ALA C 472 47.043 90.726 63.706 1.00 73.77 C ATOM 2254 O ALA C 472 46.032 90.354 64.308 1.00 72.97 O ATOM 2255 CB ALA C 472 48.698 92.588 63.964 1.00 72.13 C ATOM 2256 N PHE C 473 47.144 90.726 62.381 1.00 70.34 N ATOM 2257 CA PHE C 473 46.046 90.310 61.522 1.00 68.99 C ATOM 2258 C PHE C 473 45.226 89.142 62.047 1.00 69.68 C ATOM 2259 O PHE C 473 43.996 89.194 62.053 1.00 67.87 O ATOM 2260 CB PHE C 473 46.553 89.954 60.127 1.00 67.47 C ATOM 2261 CG PHE C 473 45.535 89.235 59.307 1.00 66.35 C ATOM 2262 CD1 PHE C 473 45.365 87.862 59.436 1.00 66.26 C ATOM 2263 CD2 PHE C 473 44.673 89.939 58.482 1.00 66.44 C ATOM 2264 CE1 PHE C 473 44.350 87.205 58.764 1.00 67.33 C ATOM 2265 CE2 PHE C 473 43.655 89.292 57.807 1.00 68.32 C ATOM 2266 CZ PHE C 473 43.490 87.922 57.948 1.00 68.37 C ATOM 2267 N LEU C 474 45.901 88.073 62.452 1.00 72.43 N ATOM 2268 CA LEU C 474 45.200 86.906 62.967 1.00 74.00 C ATOM 2269 C LEU C 474 44.520 87.261 64.277 1.00 75.66 C ATOM 2270 O LEU C 474 43.336 86.969 64.459 1.00 78.03 O ATOM 2271 CB LEU C 474 46.166 85.740 63.175 1.00 71.52 C ATOM 2272 CG LEU C 474 46.788 85.191 61.889 1.00 71.68 C ATOM 2273 CD1 LEU C 474 47.775 84.097 62.244 1.00 74.30 C ATOM 2274 CD2 LEU C 474 45.706 84.658 60.961 1.00 68.91 C ATOM 2275 N LYS C 475 45.267 87.899 65.179 1.00 72.98 N ATOM 2276 CA LYS C 475 44.726 88.303 66.472 1.00 70.15 C ATOM 2277 C LYS C 475 43.410 89.053 66.324 1.00 70.01 C ATOM 2278 O LYS C 475 42.416 88.708 66.962 1.00 71.03 O ATOM 2279 CB LYS C 475 45.735 89.166 67.222 1.00 68.43 C ATOM 2280 CG LYS C 475 46.882 88.362 67.775 1.00 71.75 C ATOM 2281 CD LYS C 475 47.666 89.129 68.816 1.00 73.32 C ATOM 2282 CE LYS C 475 48.552 88.177 69.601 1.00 73.59 C ATOM 2283 NZ LYS C 475 47.740 87.085 70.213 1.00 72.78 N ATOM 2284 N VAL C 476 43.403 90.079 65.481 1.00 68.26 N ATOM 2285 CA VAL C 476 42.197 90.859 65.242 1.00 67.41 C ATOM 2286 C VAL C 476 41.085 89.974 64.700 1.00 68.57 C ATOM 2287 O VAL C 476 39.949 90.027 65.163 1.00 67.54 O ATOM 2288 CB VAL C 476 42.471 91.980 64.232 1.00 67.78 C ATOM 2289 CG1 VAL C 476 41.178 92.404 63.538 1.00 66.41 C ATOM 2290 CG2 VAL C 476 43.106 93.157 64.952 1.00 68.22 C ATOM 2291 N SER C 477 41.427 89.159 63.712 1.00 72.30 N ATOM 2292 CA SER C 477 40.474 88.256 63.082 1.00 75.85 C ATOM 2293 C SER C 477 39.858 87.259 64.064 1.00 75.99 C ATOM 2294 O SER C 477 38.677 86.921 63.960 1.00 75.63 O ATOM 2295 CB SER C 477 41.168 87.493 61.952 1.00 77.97 C ATOM 2296 OG SER C 477 41.826 88.388 61.073 1.00 81.15 O ATOM 2297 N SER C 478 40.664 86.796 65.015 1.00 74.79 N ATOM 2298 CA SER C 478 40.221 85.819 66.003 1.00 73.58 C ATOM 2299 C SER C 478 38.994 86.243 66.806 1.00 74.47 C ATOM 2300 O SER C 478 38.603 85.559 67.753 1.00 77.09 O ATOM 2301 CB SER C 478 41.362 85.483 66.971 1.00 72.03 C ATOM 2302 OG SER C 478 41.651 86.575 67.825 1.00 67.84 O ATOM 2303 N VAL C 479 38.387 87.365 66.442 1.00 72.98 N ATOM 2304 CA VAL C 479 37.203 87.816 67.152 1.00 72.47 C ATOM 2305 C VAL C 479 36.152 88.351 66.197 1.00 73.72 C ATOM 2306 O VAL C 479 35.330 89.178 66.577 1.00 74.74 O ATOM 2307 CB VAL C 479 37.535 88.910 68.179 1.00 74.22 C ATOM 2308 CG1 VAL C 479 38.531 88.376 69.207 1.00 75.24 C ATOM 2309 CG2 VAL C 479 38.077 90.138 67.468 1.00 75.85 C ATOM 2310 N PHE C 480 36.190 87.878 64.956 1.00 76.05 N ATOM 2311 CA PHE C 480 35.220 88.287 63.944 1.00 78.44 C ATOM 2312 C PHE C 480 33.899 87.553 64.161 1.00 82.82 C ATOM 2313 O PHE C 480 33.846 86.322 64.091 1.00 82.67 O ATOM 2314 CB PHE C 480 35.736 87.956 62.540 1.00 78.41 C ATOM 2315 CG PHE C 480 34.693 88.104 61.450 1.00 76.88 C ATOM 2316 CD1 PHE C 480 34.749 89.168 60.552 1.00 77.86 C ATOM 2317 CD2 PHE C 480 33.650 87.183 61.329 1.00 73.51 C ATOM 2318 CE1 PHE C 480 33.788 89.316 59.556 1.00 76.43 C ATOM 2319 CE2 PHE C 480 32.687 87.321 60.341 1.00 73.83 C ATOM 2320 CZ PHE C 480 32.754 88.389 59.452 1.00 76.74 C ATOM 2321 N LYS C 481 32.836 88.309 64.417 1.00 87.32 N ATOM 2322 CA LYS C 481 31.511 87.732 64.613 1.00 90.21 C ATOM 2323 C LYS C 481 30.654 88.331 63.514 1.00 93.65 C ATOM 2324 O LYS C 481 30.700 89.536 63.282 1.00 92.82 O ATOM 2325 CB LYS C 481 30.951 88.102 65.992 1.00 88.84 C ATOM 2326 CG LYS C 481 31.955 87.931 67.128 1.00 90.44 C ATOM 2327 CD LYS C 481 32.677 86.586 67.048 1.00 92.63 C ATOM 2328 CE LYS C 481 33.997 86.617 67.819 1.00 93.60 C ATOM 2329 NZ LYS C 481 34.823 85.381 67.662 1.00 92.59 N ATOM 2330 N ASP C 482 29.886 87.491 62.829 1.00 99.78 N ATOM 2331 CA ASP C 482 29.047 87.958 61.733 1.00104.48 C ATOM 2332 C ASP C 482 28.153 89.129 62.139 1.00105.37 C ATOM 2333 O ASP C 482 27.421 89.684 61.313 1.00104.58 O ATOM 2334 CB ASP C 482 28.188 86.811 61.197 1.00107.11 C ATOM 2335 CG ASP C 482 27.589 87.128 59.843 1.00111.93 C ATOM 2336 OD1 ASP C 482 28.371 87.354 58.890 1.00113.73 O ATOM 2337 OD2 ASP C 482 26.344 87.158 59.731 1.00114.23 O ATOM 2338 N GLU C 483 28.229 89.497 63.417 1.00105.55 N ATOM 2339 CA GLU C 483 27.454 90.601 63.971 1.00105.18 C ATOM 2340 C GLU C 483 27.555 91.831 63.052 1.00105.40 C ATOM 2341 O GLU C 483 28.325 91.839 62.093 1.00106.75 O ATOM 2342 CB GLU C 483 27.972 90.919 65.381 1.00103.49 C ATOM 2343 CG GLU C 483 27.008 91.674 66.282 1.00103.16 C ATOM 2344 CD GLU C 483 26.865 93.130 65.894 1.00104.86 C ATOM 2345 OE1 GLU C 483 27.907 93.807 65.766 1.00104.86 O ATOM 2346 OE2 GLU C 483 25.717 93.598 65.720 1.00104.54 O ATOM 2347 N ALA C 484 26.772 92.863 63.346 1.00103.94 N ATOM 2348 CA ALA C 484 26.751 94.077 62.537 1.00100.64 C ATOM 2349 C ALA C 484 27.928 95.024 62.749 1.00 97.58 C ATOM 2350 O ALA C 484 28.662 95.325 61.813 1.00 94.28 O ATOM 2351 CB ALA C 484 25.440 94.822 62.774 1.00101.88 C ATOM 2352 N THR C 485 28.102 95.501 63.975 1.00 99.01 N ATOM 2353 CA THR C 485 29.181 96.436 64.279 1.00100.06 C ATOM 2354 C THR C 485 30.509 95.776 64.630 1.00101.10 C ATOM 2355 O THR C 485 31.564 96.383 64.465 1.00102.97 O ATOM 2356 CB THR C 485 28.799 97.375 65.445 1.00 98.71 C ATOM 2357 OG1 THR C 485 28.632 96.606 66.644 1.00 97.14 O ATOM 2358 CG2 THR C 485 27.502 98.123 65.131 1.00 97.79 C ATOM 2359 N VAL C 486 30.467 94.540 65.113 1.00 99.79 N ATOM 2360 CA VAL C 486 31.700 93.862 65.483 1.00 97.75 C ATOM 2361 C VAL C 486 32.526 93.451 64.282 1.00 97.44 C ATOM 2362 O VAL C 486 33.746 93.572 64.308 1.00 98.91 O ATOM 2363 CB VAL C 486 31.430 92.622 66.351 1.00 97.55 C ATOM 2364 CG1 VAL C 486 32.740 91.902 66.660 1.00 93.73 C ATOM 2365 CG2 VAL C 486 30.751 93.048 67.643 1.00 98.94 C ATOM 2366 N ARG C 487 31.883 92.965 63.227 1.00 98.42 N ATOM 2367 CA ARG C 487 32.645 92.563 62.050 1.00102.33 C ATOM 2368 C ARG C 487 33.137 93.817 61.341 1.00102.44 C ATOM 2369 O ARG C 487 34.159 93.798 60.656 1.00102.04 O ATOM 2370 CB ARG C 487 31.792 91.728 61.090 1.00105.86 C ATOM 2371 CG ARG C 487 30.934 92.546 60.150 1.00111.56 C ATOM 2372 CD ARG C 487 30.176 91.670 59.172 1.00115.49 C ATOM 2373 NE ARG C 487 29.238 92.465 58.387 1.00120.24 N ATOM 2374 CZ ARG C 487 28.355 91.958 57.536 1.00123.62 C ATOM 2375 NH1 ARG C 487 28.287 90.644 57.354 1.00125.84 N ATOM 2376 NH2 ARG C 487 27.534 92.765 56.875 1.00123.90 N ATOM 2377 N MET C 488 32.402 94.910 61.514 1.00103.33 N ATOM 2378 CA MET C 488 32.776 96.167 60.890 1.00104.59 C ATOM 2379 C MET C 488 34.016 96.700 61.590 1.00103.51 C ATOM 2380 O MET C 488 34.854 97.345 60.969 1.00107.56 O ATOM 2381 CB MET C 488 31.637 97.178 60.997 1.00109.40 C ATOM 2382 CG MET C 488 31.754 98.344 60.028 1.00115.93 C ATOM 2383 SD MET C 488 30.301 99.424 60.061 1.00123.56 S ATOM 2384 CE MET C 488 29.132 98.477 59.043 1.00120.47 C ATOM 2385 N ALA C 489 34.131 96.425 62.887 1.00100.01 N ATOM 2386 CA ALA C 489 35.288 96.865 63.661 1.00 96.14 C ATOM 2387 C ALA C 489 36.485 96.036 63.222 1.00 94.33 C ATOM 2388 O ALA C 489 37.550 96.571 62.908 1.00 96.00 O ATOM 2389 CB ALA C 489 35.038 96.668 65.144 1.00 95.58 C ATOM 2390 N VAL C 490 36.295 94.721 63.204 1.00 90.35 N ATOM 2391 CA VAL C 490 37.339 93.795 62.793 1.00 85.43 C ATOM 2392 C VAL C 490 37.788 94.119 61.373 1.00 81.75 C ATOM 2393 O VAL C 490 38.981 94.280 61.120 1.00 78.03 O ATOM 2394 CB VAL C 490 36.837 92.331 62.849 1.00 84.70 C ATOM 2395 CG1 VAL C 490 37.854 91.404 62.212 1.00 86.44 C ATOM 2396 CG2 VAL C 490 36.597 91.924 64.294 1.00 82.45 C ATOM 2397 N GLN C 491 36.827 94.224 60.455 1.00 80.82 N ATOM 2398 CA GLN C 491 37.126 94.527 59.058 1.00 81.47 C ATOM 2399 C GLN C 491 38.018 95.739 58.894 1.00 82.98 C ATOM 2400 O GLN C 491 39.079 95.653 58.282 1.00 86.46 O ATOM 2401 CB GLN C 491 35.846 94.760 58.259 1.00 81.16 C ATOM 2402 CG GLN C 491 35.094 93.499 57.909 1.00 85.67 C ATOM 2403 CD GLN C 491 33.914 93.763 56.991 1.00 88.95 C ATOM 2404 OE1 GLN C 491 34.079 94.265 55.875 1.00 85.51 O ATOM 2405 NE2 GLN C 491 32.715 93.423 57.458 1.00 91.42 N ATOM 2406 N ASP C 492 37.588 96.871 59.433 1.00 82.80 N ATOM 2407 CA ASP C 492 38.371 98.088 59.312 1.00 85.20 C ATOM 2408 C ASP C 492 39.738 97.960 59.959 1.00 84.66 C ATOM 2409 O ASP C 492 40.719 98.505 59.451 1.00 84.22 O ATOM 2410 CB ASP C 492 37.608 99.262 59.907 1.00 91.02 C ATOM 2411 CG ASP C 492 36.339 99.564 59.139 1.00 97.94 C ATOM 2412 OD1 ASP C 492 36.407 99.635 57.891 1.00101.04 O ATOM 2413 OD2 ASP C 492 35.277 99.733 59.777 1.00102.87 O ATOM 2414 N ALA C 493 39.808 97.244 61.076 1.00 83.72 N ATOM 2415 CA ALA C 493 41.088 97.043 61.745 1.00 82.68 C ATOM 2416 C ALA C 493 42.039 96.445 60.705 1.00 81.66 C ATOM 2417 O ALA C 493 43.097 97.004 60.410 1.00 78.31 O ATOM 2418 CB ALA C 493 40.919 96.089 62.927 1.00 79.13 C ATOM 2419 N VAL C 494 41.633 95.308 60.148 1.00 82.05 N ATOM 2420 CA VAL C 494 42.404 94.611 59.129 1.00 79.90 C ATOM 2421 C VAL C 494 42.630 95.524 57.935 1.00 80.69 C ATOM 2422 O VAL C 494 43.745 95.636 57.438 1.00 81.75 O ATOM 2423 CB VAL C 494 41.666 93.336 58.665 1.00 79.06 C ATOM 2424 CG1 VAL C 494 42.212 92.860 57.325 1.00 80.76 C ATOM 2425 CG2 VAL C 494 41.815 92.245 59.721 1.00 76.82 C ATOM 2426 N ASP C 495 41.566 96.174 57.478 1.00 81.26 N ATOM 2427 CA ASP C 495 41.659 97.087 56.348 1.00 83.57 C ATOM 2428 C ASP C 495 42.802 98.079 56.544 1.00 84.46 C ATOM 2429 O ASP C 495 43.551 98.364 55.614 1.00 84.64 O ATOM 2430 CB ASP C 495 40.344 97.849 56.174 1.00 87.29 C ATOM 2431 CG ASP C 495 39.259 97.007 55.524 1.00 92.35 C ATOM 2432 OD1 ASP C 495 39.446 96.595 54.359 1.00 93.92 O ATOM 2433 OD2 ASP C 495 38.221 96.761 56.175 1.00 94.84 O ATOM 2434 N ALA C 496 42.932 98.598 57.760 1.00 85.43 N ATOM 2435 CA ALA C 496 43.985 99.561 58.070 1.00 85.34 C ATOM 2436 C ALA C 496 45.348 98.877 58.148 1.00 85.57 C ATOM 2437 O ALA C 496 46.219 99.111 57.304 1.00 82.98 O ATOM 2438 CB ALA C 496 43.676 100.258 59.389 1.00 85.03 C ATOM 2439 N LEU C 497 45.516 98.037 59.170 1.00 85.20 N ATOM 2440 CA LEU C 497 46.752 97.294 59.396 1.00 80.99 C ATOM 2441 C LEU C 497 47.409 96.907 58.079 1.00 81.59 C ATOM 2442 O LEU C 497 48.609 97.089 57.909 1.00 81.80 O ATOM 2443 CB LEU C 497 46.468 96.027 60.207 1.00 76.71 C ATOM 2444 CG LEU C 497 47.686 95.239 60.700 1.00 75.61 C ATOM 2445 CD1 LEU C 497 48.381 95.999 61.826 1.00 71.84 C ATOM 2446 CD2 LEU C 497 47.244 93.874 61.196 1.00 75.77 C ATOM 2447 N MET C 498 46.616 96.384 57.148 1.00 83.87 N ATOM 2448 CA MET C 498 47.131 95.967 55.845 1.00 86.97 C ATOM 2449 C MET C 498 47.359 97.133 54.895 1.00 88.54 C ATOM 2450 O MET C 498 48.368 97.177 54.195 1.00 88.51 O ATOM 2451 CB MET C 498 46.179 94.969 55.192 1.00 89.37 C ATOM 2452 CG MET C 498 45.925 93.721 56.018 1.00 95.88 C ATOM 2453 SD MET C 498 47.407 92.756 56.391 1.00 98.46 S ATOM 2454 CE MET C 498 47.593 91.854 54.886 1.00 97.69 C ATOM 2455 N GLN C 499 46.420 98.069 54.858 1.00 91.83 N ATOM 2456 CA GLN C 499 46.560 99.233 53.989 1.00 96.14 C ATOM 2457 C GLN C 499 47.946 99.819 54.225 1.00 96.52 C ATOM 2458 O GLN C 499 48.606 100.286 53.298 1.00 94.95 O ATOM 2459 CB GLN C 499 45.494 100.282 54.331 1.00100.05 C ATOM 2460 CG GLN C 499 45.596 101.586 53.539 1.00101.78 C ATOM 2461 CD GLN C 499 45.124 101.449 52.107 1.00103.07 C ATOM 2462 OE1 GLN C 499 43.949 101.186 51.852 1.00102.03 O ATOM 2463 NE2 GLN C 499 46.038 101.630 51.160 1.00104.79 N ATOM 2464 N LYS C 500 48.373 99.771 55.482 1.00 98.12 N ATOM 2465 CA LYS C 500 49.669 100.289 55.897 1.00 99.96 C ATOM 2466 C LYS C 500 50.831 99.498 55.303 1.00102.21 C ATOM 2467 O LYS C 500 51.541 99.987 54.422 1.00103.80 O ATOM 2468 CB LYS C 500 49.764 100.266 57.423 1.00 98.92 C ATOM 2469 CG LYS C 500 50.940 101.028 57.990 1.00 99.40 C ATOM 2470 CD LYS C 500 50.869 101.075 59.505 1.00102.12 C ATOM 2471 CE LYS C 500 51.827 102.104 60.073 1.00105.13 C ATOM 2472 NZ LYS C 500 51.783 102.147 61.562 1.00107.80 N ATOM 2473 N ALA C 501 51.016 98.275 55.790 1.00102.53 N ATOM 2474 CA ALA C 501 52.094 97.407 55.330 1.00104.06 C ATOM 2475 C ALA C 501 52.178 97.204 53.809 1.00106.41 C ATOM 2476 O ALA C 501 53.259 97.311 53.229 1.00107.33 O ATOM 2477 CB ALA C 501 51.995 96.062 56.029 1.00102.36 C ATOM 2478 N PHE C 502 51.056 96.907 53.157 1.00107.94 N ATOM 2479 CA PHE C 502 51.076 96.697 51.711 1.00110.52 C ATOM 2480 C PHE C 502 51.518 97.936 50.941 1.00112.81 C ATOM 2481 O PHE C 502 51.750 97.874 49.736 1.00112.19 O ATOM 2482 CB PHE C 502 49.705 96.243 51.195 1.00112.09 C ATOM 2483 CG PHE C 502 49.479 94.755 51.290 1.00113.88 C ATOM 2484 CD1 PHE C 502 50.432 93.859 50.817 1.00114.41 C ATOM 2485 CD2 PHE C 502 48.304 94.248 51.836 1.00115.09 C ATOM 2486 CE1 PHE C 502 50.218 92.485 50.888 1.00113.44 C ATOM 2487 CE2 PHE C 502 48.084 92.875 51.908 1.00114.24 C ATOM 2488 CZ PHE C 502 49.042 91.994 51.435 1.00113.54 C ATOM 2489 N ASN C 503 51.622 99.063 51.637 1.00116.92 N ATOM 2490 CA ASN C 503 52.057 100.301 51.004 1.00120.21 C ATOM 2491 C ASN C 503 53.313 100.827 51.690 1.00120.70 C ATOM 2492 O ASN C 503 53.253 101.710 52.550 1.00120.22 O ATOM 2493 CB ASN C 503 50.946 101.356 51.043 1.00123.01 C ATOM 2494 CG ASN C 503 49.791 101.027 50.106 1.00125.00 C ATOM 2495 OD1 ASN C 503 49.024 100.094 50.350 1.00126.71 O ATOM 2496 ND2 ASN C 503 49.669 101.790 49.023 1.00124.61 N ATOM 2497 N SER C 504 54.443 100.246 51.294 1.00121.23 N ATOM 2498 CA SER C 504 55.771 100.586 51.803 1.00120.86 C ATOM 2499 C SER C 504 56.714 99.485 51.331 1.00120.17 C ATOM 2500 O SER C 504 56.978 98.535 52.068 1.00121.03 O ATOM 2501 CB SER C 504 55.779 100.655 53.337 1.00120.51 C ATOM 2502 OG SER C 504 55.527 99.388 53.921 1.00117.72 O ATOM 2503 N SER C 505 57.201 99.620 50.096 1.00118.46 N ATOM 2504 CA SER C 505 58.107 98.647 49.472 1.00115.92 C ATOM 2505 C SER C 505 59.017 97.888 50.441 1.00113.79 C ATOM 2506 O SER C 505 59.468 96.779 50.144 1.00113.03 O ATOM 2507 CB SER C 505 58.954 99.340 48.400 1.00115.01 C ATOM 2508 OG SER C 505 58.138 99.821 47.345 1.00113.33 O ATOM 2509 N SER C 506 59.289 98.496 51.593 1.00109.99 N ATOM 2510 CA SER C 506 60.115 97.893 52.633 1.00105.78 C ATOM 2511 C SER C 506 59.329 96.760 53.304 1.00105.27 C ATOM 2512 O SER C 506 59.328 96.623 54.533 1.00102.95 O ATOM 2513 CB SER C 506 60.461 98.962 53.661 1.00103.87 C ATOM 2514 OG SER C 506 59.298 99.699 53.998 1.00101.17 O ATOM 2515 N PHE C 507 58.673 95.943 52.479 1.00105.22 N ATOM 2516 CA PHE C 507 57.844 94.836 52.957 1.00102.13 C ATOM 2517 C PHE C 507 57.622 93.797 51.848 1.00101.19 C ATOM 2518 O PHE C 507 57.142 94.141 50.765 1.00102.24 O ATOM 2519 CB PHE C 507 56.493 95.394 53.400 1.00 97.99 C ATOM 2520 CG PHE C 507 55.649 94.423 54.159 1.00 93.31 C ATOM 2521 CD1 PHE C 507 56.030 93.999 55.425 1.00 90.09 C ATOM 2522 CD2 PHE C 507 54.455 93.954 53.622 1.00 91.00 C ATOM 2523 CE1 PHE C 507 55.234 93.126 56.147 1.00 89.26 C ATOM 2524 CE2 PHE C 507 53.650 93.078 54.337 1.00 88.22 C ATOM 2525 CZ PHE C 507 54.041 92.662 55.603 1.00 88.46 C ATOM 2526 N ASN C 508 57.968 92.536 52.117 1.00 98.21 N ATOM 2527 CA ASN C 508 57.784 91.466 51.133 1.00 94.26 C ATOM 2528 C ASN C 508 56.419 90.817 51.316 1.00 90.98 C ATOM 2529 O ASN C 508 56.180 90.106 52.292 1.00 89.62 O ATOM 2530 CB ASN C 508 58.872 90.393 51.267 1.00 96.16 C ATOM 2531 CG ASN C 508 58.790 89.332 50.168 1.00 96.42 C ATOM 2532 OD1 ASN C 508 57.764 88.674 49.993 1.00 97.53 O ATOM 2533 ND2 ASN C 508 59.879 89.164 49.428 1.00 96.28 N ATOM 2534 N SER C 509 55.534 91.071 50.361 1.00 88.43 N ATOM 2535 CA SER C 509 54.178 90.543 50.374 1.00 85.50 C ATOM 2536 C SER C 509 54.118 89.011 50.422 1.00 84.74 C ATOM 2537 O SER C 509 53.286 88.434 51.130 1.00 83.42 O ATOM 2538 CB SER C 509 53.441 91.064 49.140 1.00 84.73 C ATOM 2539 OG SER C 509 54.295 91.041 48.007 1.00 83.58 O ATOM 2540 N ASN C 510 55.000 88.358 49.669 1.00 82.36 N ATOM 2541 CA ASN C 510 55.046 86.901 49.625 1.00 78.42 C ATOM 2542 C ASN C 510 55.428 86.297 50.966 1.00 77.99 C ATOM 2543 O ASN C 510 54.856 85.289 51.378 1.00 78.21 O ATOM 2544 CB ASN C 510 56.016 86.455 48.538 1.00 78.13 C ATOM 2545 CG ASN C 510 55.515 86.804 47.148 1.00 82.60 C ATOM 2546 OD1 ASN C 510 54.903 85.977 46.463 1.00 82.90 O ATOM 2547 ND2 ASN C 510 55.749 88.045 46.730 1.00 83.05 N ATOM 2548 N THR C 511 56.386 86.919 51.647 1.00 78.43 N ATOM 2549 CA THR C 511 56.834 86.452 52.959 1.00 76.66 C ATOM 2550 C THR C 511 55.658 86.453 53.924 1.00 74.81 C ATOM 2551 O THR C 511 55.595 85.651 54.856 1.00 73.55 O ATOM 2552 CB THR C 511 57.927 87.365 53.540 1.00 77.88 C ATOM 2553 OG1 THR C 511 59.060 87.375 52.663 1.00 79.62 O ATOM 2554 CG2 THR C 511 58.353 86.875 54.923 1.00 76.74 C ATOM 2555 N PHE C 512 54.734 87.374 53.696 1.00 75.33 N ATOM 2556 CA PHE C 512 53.545 87.485 54.526 1.00 76.39 C ATOM 2557 C PHE C 512 52.635 86.300 54.233 1.00 74.81 C ATOM 2558 O PHE C 512 52.449 85.415 55.074 1.00 73.92 O ATOM 2559 CB PHE C 512 52.806 88.784 54.207 1.00 77.79 C ATOM 2560 CG PHE C 512 51.462 88.889 54.859 1.00 77.07 C ATOM 2561 CD1 PHE C 512 51.354 88.954 56.247 1.00 76.84 C ATOM 2562 CD2 PHE C 512 50.303 88.897 54.085 1.00 73.72 C ATOM 2563 CE1 PHE C 512 50.110 89.021 56.859 1.00 77.43 C ATOM 2564 CE2 PHE C 512 49.056 88.964 54.677 1.00 73.41 C ATOM 2565 CZ PHE C 512 48.955 89.026 56.072 1.00 78.26 C ATOM 2566 N LEU C 513 52.075 86.303 53.027 1.00 72.46 N ATOM 2567 CA LEU C 513 51.181 85.249 52.571 1.00 70.45 C ATOM 2568 C LEU C 513 51.683 83.893 53.051 1.00 67.32 C ATOM 2569 O LEU C 513 50.895 83.016 53.392 1.00 66.10 O ATOM 2570 CB LEU C 513 51.088 85.287 51.037 1.00 71.52 C ATOM 2571 CG LEU C 513 50.241 84.267 50.267 1.00 73.21 C ATOM 2572 CD1 LEU C 513 51.017 82.967 50.120 1.00 74.68 C ATOM 2573 CD2 LEU C 513 48.901 84.044 50.968 1.00 72.29 C ATOM 2574 N THR C 514 53.000 83.736 53.093 1.00 65.51 N ATOM 2575 CA THR C 514 53.602 82.487 53.535 1.00 65.81 C ATOM 2576 C THR C 514 53.443 82.280 55.046 1.00 66.15 C ATOM 2577 O THR C 514 52.726 81.380 55.490 1.00 65.04 O ATOM 2578 CB THR C 514 55.101 82.442 53.157 1.00 63.29 C ATOM 2579 OG1 THR C 514 55.228 82.436 51.732 1.00 60.22 O ATOM 2580 CG2 THR C 514 55.770 81.194 53.719 1.00 62.78 C ATOM 2581 N ARG C 515 54.107 83.115 55.832 1.00 66.31 N ATOM 2582 CA ARG C 515 54.034 83.009 57.278 1.00 69.49 C ATOM 2583 C ARG C 515 52.591 83.051 57.773 1.00 73.60 C ATOM 2584 O ARG C 515 52.295 82.714 58.926 1.00 74.84 O ATOM 2585 CB ARG C 515 54.857 84.127 57.901 1.00 68.78 C ATOM 2586 CG ARG C 515 56.332 83.982 57.594 1.00 69.17 C ATOM 2587 CD ARG C 515 56.867 82.669 58.152 1.00 67.72 C ATOM 2588 NE ARG C 515 56.800 82.646 59.611 1.00 66.36 N ATOM 2589 CZ ARG C 515 57.060 81.579 60.356 1.00 67.02 C ATOM 2590 NH1 ARG C 515 57.404 80.431 59.785 1.00 67.82 N ATOM 2591 NH2 ARG C 515 56.985 81.661 61.674 1.00 66.58 N ATOM 2592 N LEU C 516 51.694 83.468 56.889 1.00 73.69 N ATOM 2593 CA LEU C 516 50.286 83.528 57.226 1.00 73.47 C ATOM 2594 C LEU C 516 49.769 82.101 57.115 1.00 73.96 C ATOM 2595 O LEU C 516 49.206 81.563 58.068 1.00 75.76 O ATOM 2596 CB LEU C 516 49.558 84.461 56.251 1.00 74.93 C ATOM 2597 CG LEU C 516 48.065 84.776 56.421 1.00 75.28 C ATOM 2598 CD1 LEU C 516 47.234 83.690 55.768 1.00 77.04 C ATOM 2599 CD2 LEU C 516 47.718 84.935 57.899 1.00 73.86 C ATOM 2600 N LEU C 517 49.989 81.487 55.954 1.00 72.97 N ATOM 2601 CA LEU C 517 49.559 80.114 55.707 1.00 72.89 C ATOM 2602 C LEU C 517 50.189 79.169 56.718 1.00 75.04 C ATOM 2603 O LEU C 517 49.591 78.165 57.107 1.00 74.45 O ATOM 2604 CB LEU C 517 49.960 79.668 54.300 1.00 71.61 C ATOM 2605 CG LEU C 517 49.262 80.321 53.108 1.00 73.04 C ATOM 2606 CD1 LEU C 517 49.859 79.789 51.814 1.00 72.19 C ATOM 2607 CD2 LEU C 517 47.772 80.031 53.169 1.00 73.65 C ATOM 2608 N VAL C 518 51.409 79.491 57.133 1.00 77.16 N ATOM 2609 CA VAL C 518 52.120 78.671 58.098 1.00 79.19 C ATOM 2610 C VAL C 518 51.481 78.759 59.470 1.00 80.94 C ATOM 2611 O VAL C 518 51.460 77.774 60.207 1.00 82.64 O ATOM 2612 CB VAL C 518 53.589 79.089 58.192 1.00 81.13 C ATOM 2613 CG1 VAL C 518 54.208 78.545 59.464 1.00 81.98 C ATOM 2614 CG2 VAL C 518 54.336 78.565 56.981 1.00 83.37 C ATOM 2615 N HIS C 519 50.963 79.936 59.816 1.00 82.25 N ATOM 2616 CA HIS C 519 50.298 80.121 61.102 1.00 84.54 C ATOM 2617 C HIS C 519 48.874 79.566 61.075 1.00 83.81 C ATOM 2618 O HIS C 519 48.316 79.201 62.112 1.00 84.26 O ATOM 2619 CB HIS C 519 50.286 81.595 61.490 1.00 87.28 C ATOM 2620 CG HIS C 519 51.451 81.994 62.336 1.00 90.21 C ATOM 2621 ND1 HIS C 519 51.714 81.406 63.554 1.00 89.58 N ATOM 2622 CD2 HIS C 519 52.427 82.912 62.142 1.00 91.83 C ATOM 2623 CE1 HIS C 519 52.803 81.945 64.074 1.00 90.67 C ATOM 2624 NE2 HIS C 519 53.254 82.862 63.236 1.00 91.16 N ATOM 2625 N MET C 520 48.292 79.507 59.882 1.00 81.17 N ATOM 2626 CA MET C 520 46.956 78.957 59.704 1.00 78.10 C ATOM 2627 C MET C 520 47.071 77.452 59.423 1.00 79.28 C ATOM 2628 O MET C 520 46.268 76.886 58.679 1.00 79.22 O ATOM 2629 CB MET C 520 46.255 79.639 58.532 1.00 74.12 C ATOM 2630 CG MET C 520 45.843 81.063 58.789 1.00 71.85 C ATOM 2631 SD MET C 520 44.888 81.697 57.392 1.00 75.04 S ATOM 2632 CE MET C 520 43.294 80.940 57.667 1.00 71.85 C ATOM 2633 N GLY C 521 48.083 76.818 60.015 1.00 78.26 N ATOM 2634 CA GLY C 521 48.313 75.394 59.834 1.00 74.58 C ATOM 2635 C GLY C 521 48.068 74.836 58.439 1.00 72.17 C ATOM 2636 O GLY C 521 47.717 73.664 58.295 1.00 73.11 O ATOM 2637 N LEU C 522 48.265 75.651 57.407 1.00 68.23 N ATOM 2638 CA LEU C 522 48.032 75.194 56.039 1.00 65.74 C ATOM 2639 C LEU C 522 49.302 74.787 55.296 1.00 64.62 C ATOM 2640 O LEU C 522 49.243 74.122 54.259 1.00 62.60 O ATOM 2641 CB LEU C 522 47.311 76.288 55.246 1.00 63.92 C ATOM 2642 CG LEU C 522 46.032 76.862 55.858 1.00 60.39 C ATOM 2643 CD1 LEU C 522 45.351 77.753 54.844 1.00 60.37 C ATOM 2644 CD2 LEU C 522 45.105 75.745 56.269 1.00 59.42 C ATOM 2645 N LEU C 523 50.447 75.190 55.833 1.00 66.37 N ATOM 2646 CA LEU C 523 51.739 74.893 55.220 1.00 66.99 C ATOM 2647 C LEU C 523 52.802 74.645 56.281 1.00 68.55 C ATOM 2648 O LEU C 523 52.859 75.351 57.290 1.00 70.39 O ATOM 2649 CB LEU C 523 52.167 76.058 54.331 1.00 63.47 C ATOM 2650 CG LEU C 523 53.607 76.045 53.832 1.00 59.57 C ATOM 2651 CD1 LEU C 523 53.876 74.747 53.092 1.00 60.86 C ATOM 2652 CD2 LEU C 523 53.834 77.240 52.933 1.00 56.76 C ATOM 2653 N LYS C 524 53.655 73.653 56.046 1.00 69.56 N ATOM 2654 CA LYS C 524 54.696 73.315 57.005 1.00 72.65 C ATOM 2655 C LYS C 524 55.777 74.363 57.170 1.00 74.44 C ATOM 2656 O LYS C 524 56.356 74.829 56.195 1.00 75.94 O ATOM 2657 CB LYS C 524 55.348 71.987 56.638 1.00 74.61 C ATOM 2658 CG LYS C 524 56.034 71.916 55.278 1.00 71.55 C ATOM 2659 CD LYS C 524 56.762 70.580 55.199 1.00 71.87 C ATOM 2660 CE LYS C 524 57.367 70.305 53.853 1.00 71.78 C ATOM 2661 NZ LYS C 524 57.964 68.972 53.795 1.00 71.07 N ATOM 2662 N SER C 525 56.053 74.725 58.415 1.00 76.02 N ATOM 2663 CA SER C 525 57.083 75.714 58.698 1.00 79.92 C ATOM 2664 C SER C 525 58.360 74.956 59.011 1.00 82.11 C ATOM 2665 O SER C 525 58.327 73.741 59.217 1.00 82.59 O ATOM 2666 CB SER C 525 56.688 76.572 59.902 1.00 81.95 C ATOM 2667 OG SER C 525 56.572 75.789 61.079 1.00 86.03 O ATOM 2668 N GLU C 526 59.481 75.668 59.045 1.00 82.63 N ATOM 2669 CA GLU C 526 60.759 75.041 59.340 1.00 83.61 C ATOM 2670 C GLU C 526 61.005 75.018 60.846 1.00 84.62 C ATOM 2671 O GLU C 526 62.106 74.736 61.310 1.00 82.25 O ATOM 2672 CB GLU C 526 61.888 75.787 58.632 1.00 84.35 C ATOM 2673 CG GLU C 526 63.221 75.068 58.720 1.00 88.36 C ATOM 2674 CD GLU C 526 64.285 75.700 57.858 1.00 90.17 C ATOM 2675 OE1 GLU C 526 65.408 75.157 57.816 1.00 90.70 O ATOM 2676 OE2 GLU C 526 63.994 76.735 57.222 1.00 92.95 O ATOM 2677 N ASP C 527 59.961 75.313 61.606 1.00 89.28 N ATOM 2678 CA ASP C 527 60.046 75.325 63.057 1.00 95.89 C ATOM 2679 C ASP C 527 58.756 74.756 63.639 1.00101.14 C ATOM 2680 O ASP C 527 58.024 74.031 62.957 1.00101.13 O ATOM 2681 CB ASP C 527 60.247 76.757 63.550 1.00 96.93 C ATOM 2682 CG ASP C 527 59.232 77.718 62.959 1.00101.29 C ATOM 2683 OD1 ASP C 527 59.349 78.055 61.762 1.00101.50 O ATOM 2684 OD2 ASP C 527 58.306 78.127 63.687 1.00104.75 O ATOM 2685 N LYS C 528 58.483 75.085 64.901 1.00105.02 N ATOM 2686 CA LYS C 528 57.275 74.618 65.576 1.00106.89 C ATOM 2687 C LYS C 528 56.375 75.803 65.891 1.00107.17 C ATOM 2688 O LYS C 528 56.635 76.567 66.819 1.00105.83 O ATOM 2689 CB LYS C 528 57.622 73.882 66.878 1.00107.50 C ATOM 2690 CG LYS C 528 56.418 73.222 67.563 1.00108.56 C ATOM 2691 CD LYS C 528 56.825 72.428 68.808 1.00106.90 C ATOM 2692 CE LYS C 528 55.656 71.624 69.391 1.00105.07 C ATOM 2693 NZ LYS C 528 54.557 72.459 69.961 1.00100.86 N ATOM 2694 N VAL C 529 55.319 75.952 65.103 1.00109.61 N ATOM 2695 CA VAL C 529 54.373 77.039 65.294 1.00112.22 C ATOM 2696 C VAL C 529 53.090 76.488 65.905 1.00111.82 C ATOM 2697 O VAL C 529 52.672 75.374 65.586 1.00112.51 O ATOM 2698 CB VAL C 529 54.034 77.727 63.945 1.00113.84 C ATOM 2699 CG1 VAL C 529 55.316 78.155 63.244 1.00113.45 C ATOM 2700 CG2 VAL C 529 53.238 76.779 63.055 1.00115.20 C ATOM 2701 N LYS C 530 52.473 77.254 66.796 1.00111.17 N ATOM 2702 CA LYS C 530 51.228 76.811 67.405 1.00111.96 C ATOM 2703 C LYS C 530 50.072 77.115 66.458 1.00112.90 C ATOM 2704 O LYS C 530 49.609 78.255 66.375 1.00113.57 O ATOM 2705 CB LYS C 530 50.979 77.520 68.741 1.00111.93 C ATOM 2706 CG LYS C 530 49.607 77.197 69.330 1.00110.33 C ATOM 2707 CD LYS C 530 49.314 77.942 70.617 1.00107.02 C ATOM 2708 CE LYS C 530 47.952 77.529 71.159 1.00105.66 C ATOM 2709 NZ LYS C 530 47.635 78.151 72.472 1.00104.81 N ATOM 2710 N ALA C 531 49.613 76.098 65.736 1.00112.47 N ATOM 2711 CA ALA C 531 48.502 76.291 64.815 1.00111.58 C ATOM 2712 C ALA C 531 47.296 76.792 65.610 1.00110.57 C ATOM 2713 O ALA C 531 46.939 76.233 66.651 1.00108.91 O ATOM 2714 CB ALA C 531 48.170 74.983 64.105 1.00110.40 C ATOM 2715 N ILE C 532 46.687 77.866 65.119 1.00108.67 N ATOM 2716 CA ILE C 532 45.528 78.460 65.766 1.00104.97 C ATOM 2717 C ILE C 532 44.333 77.517 65.701 1.00104.50 C ATOM 2718 O ILE C 532 44.181 76.754 64.748 1.00103.80 O ATOM 2719 CB ILE C 532 45.141 79.787 65.091 1.00103.58 C ATOM 2720 CG1 ILE C 532 44.511 79.518 63.719 1.00105.31 C ATOM 2721 CG2 ILE C 532 46.367 80.674 64.965 1.00100.54 C ATOM 2722 CD1 ILE C 532 45.379 78.719 62.755 1.00108.23 C ATOM 2723 N ALA C 533 43.483 77.588 66.718 1.00105.23 N ATOM 2724 CA ALA C 533 42.298 76.743 66.807 1.00103.99 C ATOM 2725 C ALA C 533 41.405 76.808 65.570 1.00101.40 C ATOM 2726 O ALA C 533 41.472 75.940 64.703 1.00100.60 O ATOM 2727 CB ALA C 533 41.491 77.116 68.050 1.00105.99 C ATOM 2728 N ASN C 534 40.569 77.841 65.499 1.00 98.33 N ATOM 2729 CA ASN C 534 39.647 78.004 64.384 1.00 94.55 C ATOM 2730 C ASN C 534 40.049 79.040 63.346 1.00 89.47 C ATOM 2731 O ASN C 534 40.442 80.152 63.686 1.00 88.40 O ATOM 2732 CB ASN C 534 38.265 78.362 64.903 1.00 97.63 C ATOM 2733 CG ASN C 534 37.444 79.079 63.865 1.00102.34 C ATOM 2734 OD1 ASN C 534 37.253 78.577 62.759 1.00104.07 O ATOM 2735 ND2 ASN C 534 36.961 80.268 64.206 1.00104.58 N ATOM 2736 N LEU C 535 39.901 78.676 62.077 1.00 84.79 N ATOM 2737 CA LEU C 535 40.249 79.557 60.967 1.00 84.26 C ATOM 2738 C LEU C 535 39.079 80.372 60.456 1.00 83.81 C ATOM 2739 O LEU C 535 39.152 80.942 59.366 1.00 81.47 O ATOM 2740 CB LEU C 535 40.807 78.747 59.798 1.00 85.12 C ATOM 2741 CG LEU C 535 42.231 78.196 59.876 1.00 87.03 C ATOM 2742 CD1 LEU C 535 42.426 77.392 61.159 1.00 87.62 C ATOM 2743 CD2 LEU C 535 42.494 77.342 58.636 1.00 85.19 C ATOM 2744 N TYR C 536 38.003 80.428 61.231 1.00 85.97 N ATOM 2745 CA TYR C 536 36.820 81.171 60.810 1.00 87.22 C ATOM 2746 C TYR C 536 37.103 82.666 60.726 1.00 84.41 C ATOM 2747 O TYR C 536 36.935 83.279 59.666 1.00 81.20 O ATOM 2748 CB TYR C 536 35.646 80.909 61.765 1.00 91.07 C ATOM 2749 CG TYR C 536 34.372 81.611 61.357 1.00 96.39 C ATOM 2750 CD1 TYR C 536 33.840 81.436 60.080 1.00 99.16 C ATOM 2751 CD2 TYR C 536 33.724 82.494 62.227 1.00 98.71 C ATOM 2752 CE1 TYR C 536 32.700 82.126 59.670 1.00101.39 C ATOM 2753 CE2 TYR C 536 32.580 83.193 61.826 1.00100.75 C ATOM 2754 CZ TYR C 536 32.077 83.004 60.542 1.00102.03 C ATOM 2755 OH TYR C 536 30.972 83.706 60.116 1.00104.32 O ATOM 2756 N GLY C 537 37.531 83.243 61.847 1.00 82.79 N ATOM 2757 CA GLY C 537 37.834 84.664 61.880 1.00 80.14 C ATOM 2758 C GLY C 537 38.732 85.046 60.720 1.00 76.86 C ATOM 2759 O GLY C 537 38.414 85.956 59.950 1.00 74.63 O ATOM 2760 N PRO C 538 39.879 84.361 60.578 1.00 73.94 N ATOM 2761 CA PRO C 538 40.816 84.643 59.493 1.00 71.48 C ATOM 2762 C PRO C 538 40.155 84.433 58.136 1.00 70.28 C ATOM 2763 O PRO C 538 40.117 85.338 57.307 1.00 69.66 O ATOM 2764 CB PRO C 538 41.943 83.653 59.757 1.00 70.22 C ATOM 2765 CG PRO C 538 41.950 83.567 61.245 1.00 67.93 C ATOM 2766 CD PRO C 538 40.481 83.426 61.545 1.00 71.25 C ATOM 2767 N LEU C 539 39.624 83.240 57.914 1.00 69.42 N ATOM 2768 CA LEU C 539 38.977 82.954 56.648 1.00 71.87 C ATOM 2769 C LEU C 539 37.922 83.989 56.292 1.00 75.40 C ATOM 2770 O LEU C 539 37.575 84.138 55.121 1.00 79.82 O ATOM 2771 CB LEU C 539 38.355 81.567 56.677 1.00 73.15 C ATOM 2772 CG LEU C 539 39.320 80.448 56.298 1.00 74.06 C ATOM 2773 CD1 LEU C 539 38.793 79.142 56.831 1.00 76.21 C ATOM 2774 CD2 LEU C 539 39.496 80.395 54.784 1.00 71.43 C ATOM 2775 N MET C 540 37.404 84.697 57.292 1.00 75.07 N ATOM 2776 CA MET C 540 36.404 85.730 57.035 1.00 73.20 C ATOM 2777 C MET C 540 37.110 87.060 56.845 1.00 71.20 C ATOM 2778 O MET C 540 36.749 87.856 55.974 1.00 68.32 O ATOM 2779 CB MET C 540 35.408 85.818 58.190 1.00 74.46 C ATOM 2780 CG MET C 540 34.379 84.711 58.157 1.00 76.88 C ATOM 2781 SD MET C 540 33.509 84.703 56.569 1.00 82.18 S ATOM 2782 CE MET C 540 31.779 84.854 57.113 1.00 80.27 C ATOM 2783 N ALA C 541 38.127 87.290 57.670 1.00 71.41 N ATOM 2784 CA ALA C 541 38.912 88.507 57.582 1.00 71.25 C ATOM 2785 C ALA C 541 39.551 88.527 56.196 1.00 72.24 C ATOM 2786 O ALA C 541 39.522 89.546 55.514 1.00 72.67 O ATOM 2787 CB ALA C 541 39.979 88.522 58.667 1.00 68.06 C ATOM 2788 N LEU C 542 40.114 87.389 55.788 1.00 73.93 N ATOM 2789 CA LEU C 542 40.747 87.247 54.476 1.00 75.24 C ATOM 2790 C LEU C 542 39.697 87.473 53.408 1.00 76.61 C ATOM 2791 O LEU C 542 39.930 88.156 52.415 1.00 75.49 O ATOM 2792 CB LEU C 542 41.313 85.835 54.284 1.00 76.06 C ATOM 2793 CG LEU C 542 42.570 85.363 55.017 1.00 76.82 C ATOM 2794 CD1 LEU C 542 42.914 83.950 54.574 1.00 74.78 C ATOM 2795 CD2 LEU C 542 43.722 86.289 54.701 1.00 77.28 C ATOM 2796 N ASN C 543 38.539 86.864 53.633 1.00 80.57 N ATOM 2797 CA ASN C 543 37.402 86.945 52.728 1.00 86.09 C ATOM 2798 C ASN C 543 37.130 88.385 52.301 1.00 86.30 C ATOM 2799 O ASN C 543 36.776 88.656 51.149 1.00 84.36 O ATOM 2800 CB ASN C 543 36.176 86.333 53.421 1.00 89.32 C ATOM 2801 CG ASN C 543 34.890 86.564 52.659 1.00 93.75 C ATOM 2802 OD1 ASN C 543 34.883 86.648 51.425 1.00 96.25 O ATOM 2803 ND2 ASN C 543 33.783 86.651 53.391 1.00 92.30 N ATOM 2804 N HIS C 544 37.316 89.299 53.246 1.00 85.82 N ATOM 2805 CA HIS C 544 37.105 90.720 53.022 1.00 86.32 C ATOM 2806 C HIS C 544 38.292 91.349 52.294 1.00 84.56 C ATOM 2807 O HIS C 544 38.135 91.956 51.237 1.00 84.93 O ATOM 2808 CB HIS C 544 36.889 91.401 54.380 1.00 89.32 C ATOM 2809 CG HIS C 544 36.783 92.895 54.315 1.00 92.53 C ATOM 2810 ND1 HIS C 544 35.875 93.548 53.510 1.00 93.49 N ATOM 2811 CD2 HIS C 544 37.437 93.861 55.004 1.00 91.50 C ATOM 2812 CE1 HIS C 544 35.972 94.850 53.709 1.00 93.09 C ATOM 2813 NE2 HIS C 544 36.912 95.067 54.610 1.00 91.66 N ATOM 2814 N MET C 545 39.475 91.178 52.874 1.00 82.71 N ATOM 2815 CA MET C 545 40.722 91.727 52.352 1.00 79.15 C ATOM 2816 C MET C 545 40.967 91.510 50.872 1.00 77.37 C ATOM 2817 O MET C 545 41.413 92.414 50.173 1.00 74.85 O ATOM 2818 CB MET C 545 41.898 91.147 53.130 1.00 81.35 C ATOM 2819 CG MET C 545 43.250 91.670 52.688 1.00 85.81 C ATOM 2820 SD MET C 545 44.588 90.733 53.443 1.00 92.30 S ATOM 2821 CE MET C 545 44.243 90.999 55.190 1.00 84.73 C ATOM 2822 N VAL C 546 40.694 90.305 50.397 1.00 80.22 N ATOM 2823 CA VAL C 546 40.912 89.987 48.995 1.00 84.30 C ATOM 2824 C VAL C 546 40.056 90.864 48.088 1.00 87.38 C ATOM 2825 O VAL C 546 40.373 91.059 46.912 1.00 86.64 O ATOM 2826 CB VAL C 546 40.595 88.504 48.714 1.00 85.13 C ATOM 2827 CG1 VAL C 546 40.868 88.186 47.257 1.00 86.13 C ATOM 2828 CG2 VAL C 546 41.432 87.605 49.624 1.00 84.04 C ATOM 2829 N GLN C 547 38.974 91.395 48.650 1.00 91.76 N ATOM 2830 CA GLN C 547 38.056 92.247 47.904 1.00 94.99 C ATOM 2831 C GLN C 547 38.554 93.689 47.844 1.00 95.42 C ATOM 2832 O GLN C 547 38.391 94.370 46.830 1.00 94.56 O ATOM 2833 CB GLN C 547 36.667 92.192 48.540 1.00 97.67 C ATOM 2834 CG GLN C 547 36.163 90.775 48.754 1.00102.68 C ATOM 2835 CD GLN C 547 34.710 90.719 49.178 1.00105.99 C ATOM 2836 OE1 GLN C 547 33.816 91.098 48.418 1.00107.71 O ATOM 2837 NE2 GLN C 547 34.465 90.245 50.397 1.00105.61 N ATOM 2838 N GLN C 548 39.163 94.149 48.934 1.00 97.52 N ATOM 2839 CA GLN C 548 39.702 95.502 48.984 1.00 99.55 C ATOM 2840 C GLN C 548 40.665 95.628 47.812 1.00101.47 C ATOM 2841 O GLN C 548 41.010 94.628 47.181 1.00103.38 O ATOM 2842 CB GLN C 548 40.446 95.734 50.302 1.00 98.71 C ATOM 2843 CG GLN C 548 39.656 95.308 51.530 1.00 97.31 C ATOM 2844 CD GLN C 548 38.285 95.947 51.590 1.00 95.58 C ATOM 2845 OE1 GLN C 548 38.151 97.125 51.917 1.00 96.66 O ATOM 2846 NE2 GLN C 548 37.256 95.173 51.259 1.00 92.47 N ATOM 2847 N ASP C 549 41.107 96.845 47.512 1.00101.13 N ATOM 2848 CA ASP C 549 42.010 97.025 46.391 1.00 97.79 C ATOM 2849 C ASP C 549 43.461 97.031 46.818 1.00 94.67 C ATOM 2850 O ASP C 549 44.331 96.580 46.079 1.00 92.96 O ATOM 2851 CB ASP C 549 41.691 98.315 45.650 1.00 99.01 C ATOM 2852 CG ASP C 549 41.994 98.213 44.176 1.00102.31 C ATOM 2853 OD1 ASP C 549 43.117 97.791 43.830 1.00103.31 O ATOM 2854 OD2 ASP C 549 41.109 98.548 43.361 1.00105.62 O ATOM 2855 N TYR C 550 43.721 97.535 48.016 1.00 93.98 N ATOM 2856 CA TYR C 550 45.081 97.596 48.530 1.00 96.07 C ATOM 2857 C TYR C 550 45.714 96.211 48.591 1.00 96.86 C ATOM 2858 O TYR C 550 46.828 96.047 49.091 1.00 97.66 O ATOM 2859 CB TYR C 550 45.088 98.228 49.921 1.00 98.07 C ATOM 2860 CG TYR C 550 44.381 97.413 50.988 1.00100.48 C ATOM 2861 CD1 TYR C 550 44.939 96.235 51.484 1.00 99.09 C ATOM 2862 CD2 TYR C 550 43.167 97.843 51.528 1.00102.44 C ATOM 2863 CE1 TYR C 550 44.312 95.509 52.490 1.00 99.91 C ATOM 2864 CE2 TYR C 550 42.531 97.122 52.538 1.00101.85 C ATOM 2865 CZ TYR C 550 43.111 95.960 53.016 1.00101.80 C ATOM 2866 OH TYR C 550 42.503 95.261 54.038 1.00102.51 O ATOM 2867 N PHE C 551 44.999 95.212 48.091 1.00 96.00 N ATOM 2868 CA PHE C 551 45.507 93.853 48.105 1.00 94.88 C ATOM 2869 C PHE C 551 46.199 93.505 46.797 1.00 93.87 C ATOM 2870 O PHE C 551 45.628 93.691 45.722 1.00 92.52 O ATOM 2871 CB PHE C 551 44.370 92.862 48.340 1.00 97.19 C ATOM 2872 CG PHE C 551 44.833 91.441 48.461 1.00 98.63 C ATOM 2873 CD1 PHE C 551 45.490 91.008 49.609 1.00 98.08 C ATOM 2874 CD2 PHE C 551 44.653 90.546 47.407 1.00 98.30 C ATOM 2875 CE1 PHE C 551 45.966 89.705 49.709 1.00 97.88 C ATOM 2876 CE2 PHE C 551 45.125 89.239 47.494 1.00 97.88 C ATOM 2877 CZ PHE C 551 45.784 88.818 48.647 1.00 98.37 C ATOM 2878 N PRO C 552 47.444 92.998 46.875 1.00 93.87 N ATOM 2879 CA PRO C 552 48.240 92.606 45.703 1.00 92.57 C ATOM 2880 C PRO C 552 47.573 91.443 44.969 1.00 91.73 C ATOM 2881 O PRO C 552 47.689 90.291 45.388 1.00 91.88 O ATOM 2882 CB PRO C 552 49.576 92.196 46.316 1.00 91.32 C ATOM 2883 CG PRO C 552 49.658 93.046 47.545 1.00 90.40 C ATOM 2884 CD PRO C 552 48.265 92.941 48.098 1.00 91.25 C ATOM 2885 N LYS C 553 46.876 91.748 43.878 1.00 90.45 N ATOM 2886 CA LYS C 553 46.179 90.732 43.098 1.00 89.10 C ATOM 2887 C LYS C 553 47.127 89.646 42.592 1.00 90.57 C ATOM 2888 O LYS C 553 46.738 88.790 41.796 1.00 92.13 O ATOM 2889 CB LYS C 553 45.452 91.384 41.917 1.00 84.93 C ATOM 2890 N ALA C 554 48.368 89.678 43.065 1.00 90.63 N ATOM 2891 CA ALA C 554 49.378 88.704 42.663 1.00 90.07 C ATOM 2892 C ALA C 554 49.423 87.477 43.584 1.00 87.79 C ATOM 2893 O ALA C 554 49.719 86.362 43.144 1.00 86.81 O ATOM 2894 CB ALA C 554 50.741 89.378 42.627 1.00 91.71 C ATOM 2895 N LEU C 555 49.135 87.694 44.864 1.00 84.47 N ATOM 2896 CA LEU C 555 49.140 86.622 45.851 1.00 78.96 C ATOM 2897 C LEU C 555 47.848 85.843 45.703 1.00 77.30 C ATOM 2898 O LEU C 555 47.613 84.872 46.417 1.00 76.23 O ATOM 2899 CB LEU C 555 49.213 87.212 47.258 1.00 75.69 C ATOM 2900 CG LEU C 555 50.133 88.425 47.408 1.00 72.68 C ATOM 2901 CD1 LEU C 555 49.760 89.179 48.663 1.00 70.71 C ATOM 2902 CD2 LEU C 555 51.589 87.991 47.426 1.00 69.77 C ATOM 2903 N ALA C 556 47.019 86.286 44.763 1.00 77.09 N ATOM 2904 CA ALA C 556 45.721 85.678 44.496 1.00 78.42 C ATOM 2905 C ALA C 556 45.713 84.152 44.397 1.00 78.03 C ATOM 2906 O ALA C 556 45.095 83.475 45.221 1.00 77.39 O ATOM 2907 CB ALA C 556 45.116 86.290 43.223 1.00 79.23 C ATOM 2908 N PRO C 557 46.396 83.586 43.390 1.00 76.68 N ATOM 2909 CA PRO C 557 46.412 82.127 43.253 1.00 75.84 C ATOM 2910 C PRO C 557 47.080 81.359 44.401 1.00 73.89 C ATOM 2911 O PRO C 557 46.692 80.234 44.710 1.00 71.78 O ATOM 2912 CB PRO C 557 47.119 81.924 41.917 1.00 77.59 C ATOM 2913 CG PRO C 557 48.076 83.084 41.871 1.00 77.53 C ATOM 2914 CD PRO C 557 47.214 84.222 42.341 1.00 75.63 C ATOM 2915 N LEU C 558 48.074 81.970 45.035 1.00 73.76 N ATOM 2916 CA LEU C 558 48.786 81.330 46.135 1.00 74.25 C ATOM 2917 C LEU C 558 47.917 81.105 47.360 1.00 75.37 C ATOM 2918 O LEU C 558 48.197 80.226 48.172 1.00 76.88 O ATOM 2919 CB LEU C 558 50.008 82.156 46.515 1.00 75.61 C ATOM 2920 CG LEU C 558 51.168 82.066 45.522 1.00 80.01 C ATOM 2921 CD1 LEU C 558 50.711 82.426 44.100 1.00 78.72 C ATOM 2922 CD2 LEU C 558 52.282 82.996 45.995 1.00 82.76 C ATOM 2923 N LEU C 559 46.872 81.910 47.505 1.00 76.55 N ATOM 2924 CA LEU C 559 45.950 81.762 48.627 1.00 75.88 C ATOM 2925 C LEU C 559 44.910 80.754 48.154 1.00 76.58 C ATOM 2926 O LEU C 559 44.542 79.824 48.875 1.00 77.71 O ATOM 2927 CB LEU C 559 45.259 83.092 48.945 1.00 73.09 C ATOM 2928 CG LEU C 559 45.138 83.483 50.420 1.00 70.06 C ATOM 2929 CD1 LEU C 559 44.106 84.598 50.561 1.00 67.02 C ATOM 2930 CD2 LEU C 559 44.737 82.277 51.249 1.00 68.02 C ATOM 2931 N LEU C 560 44.451 80.957 46.922 1.00 74.76 N ATOM 2932 CA LEU C 560 43.465 80.087 46.301 1.00 71.31 C ATOM 2933 C LEU C 560 43.922 78.643 46.412 1.00 74.77 C ATOM 2934 O LEU C 560 43.130 77.755 46.729 1.00 78.31 O ATOM 2935 CB LEU C 560 43.295 80.463 44.830 1.00 61.90 C ATOM 2936 CG LEU C 560 42.567 79.447 43.956 1.00 58.53 C ATOM 2937 CD1 LEU C 560 41.257 79.029 44.602 1.00 57.69 C ATOM 2938 CD2 LEU C 560 42.333 80.057 42.590 1.00 56.83 C ATOM 2939 N ALA C 561 45.211 78.426 46.164 1.00 74.04 N ATOM 2940 CA ALA C 561 45.807 77.097 46.221 1.00 70.31 C ATOM 2941 C ALA C 561 45.830 76.515 47.627 1.00 66.44 C ATOM 2942 O ALA C 561 45.511 75.345 47.828 1.00 66.21 O ATOM 2943 CB ALA C 561 47.217 77.139 45.661 1.00 68.49 C ATOM 2944 N PHE C 562 46.199 77.322 48.607 1.00 62.80 N ATOM 2945 CA PHE C 562 46.251 76.805 49.956 1.00 65.36 C ATOM 2946 C PHE C 562 44.964 76.803 50.745 1.00 67.81 C ATOM 2947 O PHE C 562 44.958 76.438 51.922 1.00 67.64 O ATOM 2948 CB PHE C 562 47.338 77.503 50.746 1.00 66.93 C ATOM 2949 CG PHE C 562 48.649 76.820 50.640 1.00 67.44 C ATOM 2950 CD1 PHE C 562 49.459 77.025 49.536 1.00 65.60 C ATOM 2951 CD2 PHE C 562 49.040 75.899 51.611 1.00 67.80 C ATOM 2952 CE1 PHE C 562 50.637 76.322 49.396 1.00 68.63 C ATOM 2953 CE2 PHE C 562 50.215 75.189 51.484 1.00 65.84 C ATOM 2954 CZ PHE C 562 51.018 75.398 50.374 1.00 68.99 C ATOM 2955 N VAL C 563 43.875 77.210 50.106 1.00 69.66 N ATOM 2956 CA VAL C 563 42.584 77.199 50.774 1.00 70.12 C ATOM 2957 C VAL C 563 41.834 75.982 50.255 1.00 70.79 C ATOM 2958 O VAL C 563 41.065 75.347 50.978 1.00 71.16 O ATOM 2959 CB VAL C 563 41.779 78.464 50.484 1.00 69.09 C ATOM 2960 CG1 VAL C 563 40.436 78.382 51.176 1.00 68.19 C ATOM 2961 CG2 VAL C 563 42.538 79.675 50.980 1.00 70.61 C ATOM 2962 N THR C 564 42.069 75.658 48.989 1.00 69.84 N ATOM 2963 CA THR C 564 41.448 74.494 48.379 1.00 68.83 C ATOM 2964 C THR C 564 42.224 73.282 48.877 1.00 71.39 C ATOM 2965 O THR C 564 41.734 72.155 48.859 1.00 73.54 O ATOM 2966 CB THR C 564 41.537 74.561 46.851 1.00 66.22 C ATOM 2967 OG1 THR C 564 42.713 75.286 46.484 1.00 64.37 O ATOM 2968 CG2 THR C 564 40.319 75.248 46.265 1.00 68.48 C ATOM 2969 N LYS C 565 43.445 73.533 49.331 1.00 73.46 N ATOM 2970 CA LYS C 565 44.306 72.477 49.845 1.00 74.28 C ATOM 2971 C LYS C 565 43.615 71.695 50.955 1.00 72.22 C ATOM 2972 O LYS C 565 43.404 72.215 52.052 1.00 74.35 O ATOM 2973 CB LYS C 565 45.603 73.074 50.399 1.00 77.66 C ATOM 2974 CG LYS C 565 46.559 72.056 51.032 1.00 79.34 C ATOM 2975 CD LYS C 565 47.316 71.251 49.979 1.00 77.83 C ATOM 2976 CE LYS C 565 48.261 70.253 50.626 1.00 75.97 C ATOM 2977 NZ LYS C 565 49.113 70.902 51.656 1.00 75.77 N ATOM 2978 N PRO C 566 43.255 70.432 50.682 1.00 68.26 N ATOM 2979 CA PRO C 566 42.592 69.568 51.659 1.00 65.99 C ATOM 2980 C PRO C 566 43.238 69.690 53.038 1.00 66.00 C ATOM 2981 O PRO C 566 44.401 69.338 53.221 1.00 67.20 O ATOM 2982 CB PRO C 566 42.782 68.190 51.051 1.00 62.94 C ATOM 2983 CG PRO C 566 42.622 68.477 49.600 1.00 61.56 C ATOM 2984 CD PRO C 566 43.462 69.713 49.412 1.00 64.92 C ATOM 2985 N ASN C 567 42.486 70.202 54.005 1.00 66.94 N ATOM 2986 CA ASN C 567 43.012 70.358 55.354 1.00 70.21 C ATOM 2987 C ASN C 567 41.946 70.371 56.444 1.00 70.39 C ATOM 2988 O ASN C 567 40.996 71.152 56.392 1.00 67.81 O ATOM 2989 CB ASN C 567 43.831 71.637 55.469 1.00 73.82 C ATOM 2990 CG ASN C 567 43.943 72.114 56.903 1.00 78.84 C ATOM 2991 OD1 ASN C 567 44.579 71.473 57.740 1.00 82.23 O ATOM 2992 ND2 ASN C 567 43.301 73.232 57.201 1.00 81.76 N ATOM 2993 N SER C 568 42.140 69.512 57.440 1.00 71.46 N ATOM 2994 CA SER C 568 41.239 69.372 58.580 1.00 71.62 C ATOM 2995 C SER C 568 40.475 70.627 59.011 1.00 71.98 C ATOM 2996 O SER C 568 39.268 70.725 58.804 1.00 71.21 O ATOM 2997 CB SER C 568 42.023 68.839 59.775 1.00 73.02 C ATOM 2998 OG SER C 568 41.268 68.980 60.961 1.00 75.95 O ATOM 2999 N ALA C 569 41.177 71.577 59.625 1.00 72.64 N ATOM 3000 CA ALA C 569 40.558 72.815 60.101 1.00 71.24 C ATOM 3001 C ALA C 569 39.925 73.663 58.990 1.00 69.40 C ATOM 3002 O ALA C 569 38.818 74.167 59.139 1.00 66.08 O ATOM 3003 CB ALA C 569 41.586 73.638 60.875 1.00 70.92 C ATOM 3004 N LEU C 570 40.626 73.827 57.878 1.00 71.55 N ATOM 3005 CA LEU C 570 40.093 74.610 56.772 1.00 75.93 C ATOM 3006 C LEU C 570 38.867 73.891 56.213 1.00 77.23 C ATOM 3007 O LEU C 570 38.371 74.215 55.134 1.00 75.35 O ATOM 3008 CB LEU C 570 41.157 74.765 55.684 1.00 80.13 C ATOM 3009 CG LEU C 570 40.921 75.686 54.483 1.00 81.78 C ATOM 3010 CD1 LEU C 570 40.756 77.137 54.928 1.00 81.55 C ATOM 3011 CD2 LEU C 570 42.115 75.562 53.551 1.00 82.31 C ATOM 3012 N GLU C 571 38.398 72.897 56.959 1.00 79.73 N ATOM 3013 CA GLU C 571 37.229 72.115 56.583 1.00 83.51 C ATOM 3014 C GLU C 571 36.191 72.274 57.684 1.00 82.73 C ATOM 3015 O GLU C 571 34.994 72.159 57.443 1.00 82.54 O ATOM 3016 CB GLU C 571 37.602 70.635 56.427 1.00 90.24 C ATOM 3017 CG GLU C 571 38.492 70.317 55.216 1.00 98.31 C ATOM 3018 CD GLU C 571 39.005 68.871 55.193 1.00101.31 C ATOM 3019 OE1 GLU C 571 38.190 67.925 55.291 1.00101.97 O ATOM 3020 OE2 GLU C 571 40.234 68.683 55.065 1.00103.43 O ATOM 3021 N SER C 572 36.661 72.553 58.894 1.00 83.29 N ATOM 3022 CA SER C 572 35.781 72.734 60.043 1.00 83.03 C ATOM 3023 C SER C 572 35.055 74.063 59.948 1.00 82.06 C ATOM 3024 O SER C 572 34.536 74.557 60.946 1.00 81.28 O ATOM 3025 CB SER C 572 36.583 72.711 61.349 1.00 86.15 C ATOM 3026 OG SER C 572 37.452 71.592 61.415 1.00 90.02 O ATOM 3027 N CYS C 573 35.039 74.649 58.755 1.00 83.74 N ATOM 3028 CA CYS C 573 34.370 75.928 58.526 1.00 87.34 C ATOM 3029 C CYS C 573 33.922 76.059 57.082 1.00 87.25 C ATOM 3030 O CYS C 573 34.134 77.090 56.446 1.00 86.77 O ATOM 3031 CB CYS C 573 35.295 77.089 58.880 1.00 89.19 C ATOM 3032 SG CYS C 573 35.551 77.297 60.652 1.00 98.82 S ATOM 3033 N SER C 574 33.297 75.000 56.584 1.00 88.10 N ATOM 3034 CA SER C 574 32.807 74.936 55.215 1.00 91.72 C ATOM 3035 C SER C 574 32.377 76.287 54.661 1.00 93.82 C ATOM 3036 O SER C 574 32.752 76.667 53.546 1.00 92.69 O ATOM 3037 CB SER C 574 31.626 73.966 55.140 1.00 94.25 C ATOM 3038 OG SER C 574 31.965 72.698 55.672 1.00 96.25 O ATOM 3039 N PHE C 575 31.582 77.001 55.453 1.00 96.56 N ATOM 3040 CA PHE C 575 31.060 78.305 55.069 1.00 99.23 C ATOM 3041 C PHE C 575 32.177 79.291 54.751 1.00 97.30 C ATOM 3042 O PHE C 575 32.415 79.621 53.585 1.00 95.23 O ATOM 3043 CB PHE C 575 30.168 78.844 56.194 1.00105.83 C ATOM 3044 CG PHE C 575 29.409 80.094 55.834 1.00113.68 C ATOM 3045 CD1 PHE C 575 28.690 80.173 54.639 1.00115.00 C ATOM 3046 CD2 PHE C 575 29.395 81.190 56.702 1.00116.40 C ATOM 3047 CE1 PHE C 575 27.967 81.323 54.315 1.00116.71 C ATOM 3048 CE2 PHE C 575 28.676 82.345 56.388 1.00117.37 C ATOM 3049 CZ PHE C 575 27.960 82.412 55.192 1.00117.76 C ATOM 3050 N ALA C 576 32.862 79.748 55.796 1.00 96.11 N ATOM 3051 CA ALA C 576 33.958 80.702 55.660 1.00 96.10 C ATOM 3052 C ALA C 576 34.832 80.421 54.437 1.00 95.47 C ATOM 3053 O ALA C 576 35.203 81.335 53.692 1.00 94.51 O ATOM 3054 CB ALA C 576 34.809 80.684 56.925 1.00 95.80 C ATOM 3055 N ARG C 577 35.151 79.148 54.235 1.00 93.61 N ATOM 3056 CA ARG C 577 35.983 78.734 53.122 1.00 92.24 C ATOM 3057 C ARG C 577 35.294 78.900 51.770 1.00 92.48 C ATOM 3058 O ARG C 577 35.769 79.662 50.932 1.00 91.63 O ATOM 3059 CB ARG C 577 36.412 77.284 53.318 1.00 92.34 C ATOM 3060 CG ARG C 577 37.305 76.739 52.221 1.00 93.88 C ATOM 3061 CD ARG C 577 37.648 75.290 52.499 1.00 93.23 C ATOM 3062 NE ARG C 577 38.434 74.691 51.431 1.00 93.01 N ATOM 3063 CZ ARG C 577 38.897 73.450 51.468 1.00 95.89 C ATOM 3064 NH1 ARG C 577 38.647 72.683 52.519 1.00 96.45 N ATOM 3065 NH2 ARG C 577 39.617 72.979 50.463 1.00 99.06 N ATOM 3066 N HIS C 578 34.185 78.193 51.553 1.00 93.76 N ATOM 3067 CA HIS C 578 33.470 78.299 50.280 1.00 97.11 C ATOM 3068 C HIS C 578 33.361 79.774 49.902 1.00 96.29 C ATOM 3069 O HIS C 578 33.493 80.145 48.732 1.00 95.85 O ATOM 3070 CB HIS C 578 32.064 77.681 50.389 1.00102.86 C ATOM 3071 CG HIS C 578 31.258 77.757 49.121 1.00108.46 C ATOM 3072 ND1 HIS C 578 29.912 77.447 49.074 1.00109.64 N ATOM 3073 CD2 HIS C 578 31.603 78.105 47.857 1.00109.04 C ATOM 3074 CE1 HIS C 578 29.466 77.603 47.840 1.00108.04 C ATOM 3075 NE2 HIS C 578 30.472 78.002 47.082 1.00107.98 N ATOM 3076 N SER C 579 33.130 80.614 50.906 1.00 94.79 N ATOM 3077 CA SER C 579 33.011 82.052 50.694 1.00 92.14 C ATOM 3078 C SER C 579 34.292 82.560 50.050 1.00 89.00 C ATOM 3079 O SER C 579 34.285 83.033 48.912 1.00 86.52 O ATOM 3080 CB SER C 579 32.798 82.762 52.031 1.00 92.04 C ATOM 3081 OG SER C 579 31.750 82.156 52.761 1.00 91.07 O ATOM 3082 N LEU C 580 35.389 82.445 50.798 1.00 85.71 N ATOM 3083 CA LEU C 580 36.701 82.880 50.342 1.00 81.80 C ATOM 3084 C LEU C 580 36.996 82.276 48.979 1.00 80.30 C ATOM 3085 O LEU C 580 37.453 82.970 48.072 1.00 80.30 O ATOM 3086 CB LEU C 580 37.776 82.440 51.335 1.00 81.27 C ATOM 3087 CG LEU C 580 38.996 83.351 51.520 1.00 81.05 C ATOM 3088 CD1 LEU C 580 40.097 82.573 52.241 1.00 79.42 C ATOM 3089 CD2 LEU C 580 39.493 83.859 50.181 1.00 77.33 C ATOM 3090 N LEU C 581 36.745 80.976 48.837 1.00 79.15 N ATOM 3091 CA LEU C 581 36.985 80.311 47.562 1.00 78.02 C ATOM 3092 C LEU C 581 36.203 81.046 46.497 1.00 76.21 C ATOM 3093 O LEU C 581 36.723 81.342 45.426 1.00 73.10 O ATOM 3094 CB LEU C 581 36.558 78.838 47.616 1.00 76.68 C ATOM 3095 CG LEU C 581 37.566 77.926 48.323 1.00 75.88 C ATOM 3096 CD1 LEU C 581 37.067 76.494 48.352 1.00 75.63 C ATOM 3097 CD2 LEU C 581 38.898 78.003 47.594 1.00 76.69 C ATOM 3098 N GLN C 582 34.951 81.357 46.800 1.00 77.88 N ATOM 3099 CA GLN C 582 34.133 82.081 45.849 1.00 81.01 C ATOM 3100 C GLN C 582 34.742 83.451 45.591 1.00 82.80 C ATOM 3101 O GLN C 582 35.003 83.818 44.442 1.00 85.29 O ATOM 3102 CB GLN C 582 32.700 82.211 46.367 1.00 80.84 C ATOM 3103 CG GLN C 582 31.850 81.011 46.009 1.00 81.47 C ATOM 3104 CD GLN C 582 31.836 80.751 44.508 1.00 82.48 C ATOM 3105 OE1 GLN C 582 31.532 79.645 44.059 1.00 84.33 O ATOM 3106 NE2 GLN C 582 32.161 81.777 43.724 1.00 80.22 N ATOM 3107 N THR C 583 34.979 84.198 46.665 1.00 81.82 N ATOM 3108 CA THR C 583 35.574 85.527 46.563 1.00 79.66 C ATOM 3109 C THR C 583 36.791 85.468 45.634 1.00 77.14 C ATOM 3110 O THR C 583 36.915 86.262 44.700 1.00 74.70 O ATOM 3111 CB THR C 583 36.021 86.037 47.963 1.00 81.92 C ATOM 3112 OG1 THR C 583 34.876 86.204 48.809 1.00 81.57 O ATOM 3113 CG2 THR C 583 36.754 87.358 47.846 1.00 83.82 C ATOM 3114 N LEU C 584 37.668 84.498 45.896 1.00 74.83 N ATOM 3115 CA LEU C 584 38.893 84.301 45.127 1.00 72.17 C ATOM 3116 C LEU C 584 38.683 83.852 43.691 1.00 73.15 C ATOM 3117 O LEU C 584 39.408 84.279 42.797 1.00 70.80 O ATOM 3118 CB LEU C 584 39.789 83.290 45.836 1.00 70.45 C ATOM 3119 CG LEU C 584 40.416 83.767 47.144 1.00 72.08 C ATOM 3120 CD1 LEU C 584 41.154 82.625 47.817 1.00 74.11 C ATOM 3121 CD2 LEU C 584 41.368 84.908 46.856 1.00 72.41 C ATOM 3122 N TYR C 585 37.704 82.983 43.463 1.00 77.40 N ATOM 3123 CA TYR C 585 37.448 82.502 42.109 1.00 81.50 C ATOM 3124 C TYR C 585 37.186 83.694 41.196 1.00 83.04 C ATOM 3125 O TYR C 585 37.419 83.626 39.988 1.00 81.40 O ATOM 3126 CB TYR C 585 36.238 81.547 42.075 1.00 82.42 C ATOM 3127 CG TYR C 585 36.444 80.181 42.721 1.00 82.30 C ATOM 3128 CD1 TYR C 585 35.370 79.318 42.917 1.00 82.58 C ATOM 3129 CD2 TYR C 585 37.699 79.767 43.168 1.00 84.11 C ATOM 3130 CE1 TYR C 585 35.535 78.086 43.548 1.00 83.34 C ATOM 3131 CE2 TYR C 585 37.873 78.535 43.802 1.00 83.40 C ATOM 3132 CZ TYR C 585 36.785 77.703 43.990 1.00 82.78 C ATOM 3133 OH TYR C 585 36.944 76.503 44.639 1.00 80.35 O ATOM 3134 N LYS C 586 36.721 84.791 41.789 1.00 86.59 N ATOM 3135 CA LYS C 586 36.407 86.002 41.040 1.00 91.90 C ATOM 3136 C LYS C 586 37.585 86.965 40.876 1.00 97.69 C ATOM 3137 O LYS C 586 37.764 87.551 39.803 1.00 98.22 O ATOM 3138 CB LYS C 586 35.236 86.733 41.703 1.00 87.35 C ATOM 3139 N VAL C 587 38.388 87.125 41.930 1.00103.24 N ATOM 3140 CA VAL C 587 39.539 88.035 41.898 1.00106.78 C ATOM 3141 C VAL C 587 40.572 87.702 40.825 1.00109.51 C ATOM 3142 O VAL C 587 40.867 88.599 40.002 1.00110.36 O ATOM 3143 CB VAL C 587 40.268 88.096 43.272 1.00106.16 C ATOM 3144 CG1 VAL C 587 39.312 88.593 44.345 1.00106.64 C ATOM 3145 CG2 VAL C 587 40.831 86.731 43.639 1.00105.76 C ATOM 3146 OXT VAL C 587 41.079 86.558 40.819 1.00113.47 O TER 3731 HOH B 101 HETATM 3732 O HOH C 3 37.641 73.218 47.936 1.00 42.74 O HETATM 3733 O HOH C 5 32.031 78.481 58.494 1.00 41.71 O HETATM 3734 O HOH C 9 56.449 76.898 55.251 1.00 48.13 O HETATM 3735 O HOH C 17 33.608 93.604 51.785 1.00 45.78 O HETATM 3736 O HOH C 18 47.406 68.960 56.437 1.00 43.84 O HETATM 3737 O HOH C 23 55.796 98.170 56.190 1.00 51.33 O HETATM 3738 O HOH C 27 59.032 84.879 49.348 1.00 66.96 O HETATM 3739 O HOH C 28 50.568 70.818 57.449 1.00 45.26 O CONECT 1952 1951 1953 2661 CONECT 2661 1952 2660 END